{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:11:02Z","timestamp":1792105862707,"version":"4.4.0"},"reference-count":82,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174078, 21907054"],"award-info":[{"award-number":["22174078, 21907054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional cyanine dyes with a symmetric structure are \u201calways\u2010on\u201d, which can easily accumulate in the liver and display high liver background fluorescence, inevitably interfering the accurate diagnosis and therapy in extrahepatic diseases. We herein report a platform of NIR\u2010II non\u2010symmetric cyanine (NSCyanine) dyes by harnessing a non\u2010symmetric strategy, which are extremely sensitive to pH\/viscosity and can be activated via a \u201cdual\u2010key\u2010and\u2010lock\u201d strategy. These NSCyanine dyes with a low p<jats:italic>K<\/jats:italic>a (&lt;4.0) only show weak fluorescence at lysosome pH (key1), however, the fluorescence can be completely switched on and significantly enhanced by intracellular viscosity (key2) in disease tissues, exhibiting high target\u2010to\u2010liver ratios up to 19.5\/1. Notably, high\u2010contrast phototheranostics in extrahepatic diseases are achieved, including intestinal metastasis\u2010imaging, acute gastritis\u2010imaging, bacteria infected wound healing, and tumor ablation via targeted combined photothermal therapy and chemotherapy.<\/jats:p>","DOI":"10.1002\/anie.202309768","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:24:38Z","timestamp":1691645078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["\u201cDual\u2010Key\u2010and\u2010Lock\u201d NIR\u2010II NSCyanines Enable High\u2010Contrast Activatable Phototheranostics in Extrahepatic Diseases"],"prefix":"10.1002","volume":"62","author":[{"given":"Yang","family":"Tian","sequence":"first","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoming","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fapu","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai\u2010Wen","family":"Pang","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4969-8158","authenticated-orcid":false,"given":"Hu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Research Center for Analytical Sciences Tianjin Key Laboratory of Biosensing and Molecular Recognition Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  94 Weijin Road 300071 Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00001"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214134"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00722C"},{"key":"e_1_2_7_5_1","unstructured":"\u00a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718917115"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0494-0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.24487"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60271K"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802546"},{"key":"e_1_2_7_11_1","unstructured":"\u00a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-016-0010"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007040"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00544"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00553"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08619"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07022"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900321"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00234G"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005899"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07711"},{"key":"e_1_2_7_22_1","unstructured":"\u00a0"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201801226"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01682"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904182"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117436"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706974"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11599"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16924-z"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.021.202101630"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00253"},{"key":"e_1_2_7_32_1","unstructured":"\u00a0"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001783"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04789A"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.9b00734"},{"key":"e_1_2_7_36_1","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09043-x"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202009986"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b04002"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c02052"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00317"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10041"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211409"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26607"},{"key":"e_1_2_7_45_1","unstructured":"\u00a0"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3110"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2820"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00719H"},{"key":"e_1_2_7_49_1","unstructured":"\u00a0"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1854"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3819"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00242"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700131"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c01066"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC04408G"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC04246B"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02112"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/bc100584d"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA02217B"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012021"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201541"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00051J"},{"key":"e_1_2_7_63_1","unstructured":"\u00a0"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03832"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c03100"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200025"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c00634"},{"key":"e_1_2_7_68_1","unstructured":"\u00a0"},{"key":"e_1_2_7_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202100398"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204851"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00950-z"},{"key":"e_1_2_7_72_1","unstructured":"\u00a0"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04404"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c01972"},{"key":"e_1_2_7_75_1","unstructured":"\u00a0"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2019.02.003"},{"key":"e_1_2_7_77_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09155"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11800"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.4.496"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00500"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00841D"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201406004"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202309768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:53:34Z","timestamp":1694710414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202309768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":82,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2023,9,18]]}},"alternative-id":["10.1002\/anie.202309768"],"URL":"https:\/\/doi.org\/10.1002\/anie.202309768","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"2023-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202309768"}}