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However, the direct self\u2010assembly of photochemically inert constituents into supramolecular nano\u2010photosensitizers (PSs) within cancer cells for precise photodynamic therapy (PDT) remains a challenge. Herein, we developed a glycosylated Aza\u2010BODIPY compound (<jats:bold>LMBP<\/jats:bold>) capable of self\u2010assembling into J\u2010aggregate nanofibers in situ for cell membrane destruction and type\u2005I PDT. <jats:bold>LMBP<\/jats:bold> selectively entered human hepatocellular carcinoma HepG2 cells and subsequently self\u2010assembled into intracellular J\u2010aggregate nanovesicles and nanofibers through supramolecular interactions. Detailed studies revealed that these J\u2010aggregate nanostructures generated superoxide radicals (O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>\u22c5) exclusively through photoinduced electron transfer, thus enabling effective PDT. Furthermore, the intracellular nanofibers exhibited an aggregation\u2010induced retention effect, which resulted in selective toxicity to HepG2 cells by disrupting their cellular membranes and synergizing with PDT for powerful tumor suppression efficacy in vivo.<\/jats:p>","DOI":"10.1002\/anie.202309786","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T15:40:28Z","timestamp":1692200428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["In Situ Self\u2010Assembled J\u2010Aggregate Nanofibers of Glycosylated Aza\u2010BODIPY for Synergetic Cell Membrane Disruption and Type\u2005I Photodynamic Therapy"],"prefix":"10.1002","volume":"62","author":[{"given":"Yi\u2010chen","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010jian","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai\u2010li","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010yu","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-7569","authenticated-orcid":false,"given":"Guo\u2010wen","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.08.010"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201901932"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05019"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106748"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008732"},{"key":"e_1_2_7_7_1","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.12.056"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01122C"},{"key":"e_1_2_7_10_1","unstructured":"\u00a0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00606"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00248-5"},{"key":"e_1_2_7_14_1","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","volume":"30","author":"Qi G. 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