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Within the realm of amyloid diseases, the use of peptides and peptidomimetics tailor\u2010designed to overcome amyloidogenesis has been an active research endeavor since the late 90s. In more recent years, incorporating nanoparticles for enhancing the biocirculation and delivery of peptide drugs has emerged as a frontier in nanomedicine, and nanoparticles have further demonstrated a potency against amyloid aggregation and cellular inflammation to rival strategies employing small molecules, peptides, and antibodies. Despite these efforts, however, a fundamental understanding of the chemistry, characteristics and function of peptido\u2010nanocomposites is lacking, and a systematic analysis of such strategy for combating a range of amyloid pathogeneses is missing. 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