{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:57:09Z","timestamp":1792799829910,"version":"4.5.0"},"reference-count":63,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB3804500"],"award-info":[{"award-number":["2022YFB3804500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21835007"],"award-info":[{"award-number":["21835007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23QA1410900"],"award-info":[{"award-number":["23QA1410900"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M723274"],"award-info":[{"award-number":["2022M723274"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Curcumin (Cur) has been clinically used for rheumatoid arthritis treatment by the means of reactive oxygen species (ROS) scavenging and immune microenvironment regulation. However, this compound has a poor water solubility and moderate antioxidative activity, favoring no further broadened application. Metal complexes of curcumin such as zinc\u2010curcumin (Zn\u2212Cur) features enhanced water solubilities, while copper\u2010curcumin (Cu\u2212Cur) shows a higher antioxidant activity but lower solubility than Zn\u2212Cur. Based on their inherent biological properties, this work proposes a nanomedicine\u2010based ion\u2010exchange strategy to enhance the efficacy of Cur for rheumatoid arthritis treatment. Copper silicate nanoparticles with hollow mesoporous structure were prepared to load water\u2010soluble Zn\u2212Cur for constructing a composite nanomedicine, which can degrade in acidic microenvironment of arthritic region, releasing Cu<jats:sup>2+<\/jats:sup> and Zn\u2212Cur. Cu<jats:sup>2+<\/jats:sup> then substitute for Zn<jats:sup>2+<\/jats:sup> in Zn\u2212Cur to form Cu\u2212Cur with a significantly enhanced antioxidative effect, capable of efficiently scavenging ROS in M1 macrophages, promoting their transition to an anti\u2010inflammatory M2 phenotype. In addition, the silicate released after nanocarrier degradation and the Zn<jats:sup>2+<\/jats:sup> released after ion exchange reaction synergistically promote the biomineralization of osteoblasts. This work provides a new approach for enhancing the antiarthritic effect of Cur via an ion\u2010exchange strategy.<\/jats:p>","DOI":"10.1002\/anie.202310061","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T17:43:53Z","timestamp":1694713433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["A Nanomedicine\u2010Enabled Ion\u2010Exchange Strategy for Enhancing Curcumin\u2010Based Rheumatoid Arthritis Therapy"],"prefix":"10.1002","volume":"62","author":[{"given":"Jiacai","family":"Yang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences (2021RU012)  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-0276","authenticated-orcid":false,"given":"Bowen","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences (2021RU012)  Shanghai 200050 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-195X","authenticated-orcid":false,"given":"Jianlin","family":"Shi","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences (2021RU012)  Shanghai 200050 P. R. China"},{"name":"Tenth People's Hospital and School of Medicine Tongji University  Shanghai 200092 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0170-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.11.019"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4466"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2022.02.002"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2021.05.019"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS01148K"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.03.029"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01375.x"},{"key":"e_1_2_7_12_1","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.09.003"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.532493"},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.009"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13040484"},{"key":"e_1_2_7_19_1","unstructured":"\u00a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4639"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b06236"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102593"},{"key":"e_1_2_7_23_1","unstructured":"\u00a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191220091"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/292760"},{"key":"e_1_2_7_26_1","unstructured":"\u00a0"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02381-6"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0727-9"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2021.101245"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00866"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2010.09.049"},{"key":"e_1_2_7_32_1","unstructured":"\u00a0"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA21593E"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111835"},{"key":"e_1_2_7_35_1","unstructured":"\u00a0"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201104763"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2019.01.001"},{"key":"e_1_2_7_38_1","unstructured":"\u00a0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09984"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23710-y"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04299"},{"key":"e_1_2_7_42_1","unstructured":"\u00a0"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08928"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2015.05.029"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202200480"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800268"},{"key":"e_1_2_7_47_1","unstructured":"\u00a0"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453676908989529"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677008991521"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.11.027"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21631"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.06.149"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3791\/60682"},{"key":"e_1_2_7_55_1","unstructured":"\u00a0"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2007.05.001"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210011"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11486"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CE01861G"},{"key":"e_1_2_7_60_1","unstructured":"\u00a0"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2007.1.2.113"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.4163\/jnh.2018.51.1.23"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2018.03.045"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202310061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:00:55Z","timestamp":1697695255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202310061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":63,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2023,10,26]]}},"alternative-id":["10.1002\/anie.202310061"],"URL":"https:\/\/doi.org\/10.1002\/anie.202310061","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]},"assertion":[{"value":"2023-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202310061"}}