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Such compounds are generally accessed through trifluoromethylation of ketones. Here we report an alternative disconnection approach for the construction of \u03b1\u2010CF<jats:sub>3<\/jats:sub> carbonyl compounds by using aroyl fluorides as bifunctional reagents for fluoroaroylation of <jats:italic>gem<\/jats:italic>\u2010difluoroalkenes through cooperative photoredox and N\u2010heterocyclic carbene (NHC) catalysis. This strategy bypasses the use of expensive or sensitive trifluoromethylation reagents and\/or the requirement for ketone pre\u2010functionalization, thus enabling an efficient and general synthetic method to access \u03b1\u2010CF<jats:sub>3<\/jats:sub>\u2010substituted ketones. A wide variety of <jats:italic>gem<\/jats:italic>\u2010difluoroalkenes and aroyl fluorides bearing a diverse set of functional groups are eligible substrates. Notably, the developed methodology also provides rapid access to mono\u2010 or difluoroalkyl ketones. Mechanistic studies reveal that merging photoredox catalysis with NHC catalysis is essential for the reaction.<\/jats:p>","DOI":"10.1002\/anie.202310288","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:19:12Z","timestamp":1696882752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Cooperative Photoredox and N\u2010Heterocyclic Carbene Catalyzed Fluoroaroylation for the Synthesis of \u03b1\u2010Trifluoromethyl\u2010Substituted Ketones"],"prefix":"10.1002","volume":"62","author":[{"given":"Xiaoye","family":"Yu","sequence":"first","affiliation":[{"name":"Organisch-Chemisches Institut Universit\u00e4t M\u00fcnster  Corrensstrasse 40 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Maity","sequence":"additional","affiliation":[{"name":"Organisch-Chemisches Institut Universit\u00e4t M\u00fcnster  Corrensstrasse 40 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