{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:19:48Z","timestamp":1791415188050,"version":"4.3.3"},"reference-count":69,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC22371299"],"award-info":[{"award-number":["NSFC22371299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC22071267"],"award-info":[{"award-number":["NSFC22071267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210414"],"award-info":[{"award-number":["BK20210414"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report herein a regiodivergent and enantioselective allyl addition to ketones with allenylsilanes through copper catalysis. With the combination of CuOAc, a Josiphos\u2010type bidentate phosphine ligand and PhSiH<jats:sub>3<\/jats:sub>, allyl addition to a variety of ketones furnishes branched products in excellent enantioselectivities. The regioselectivity is completely reversed by employing the P\u2010stereogenic ligand BenzP*, affording the linear products with excellent enantioselectivities and good <jats:italic>Z<\/jats:italic>\u2010selectivities. The linear <jats:italic>Z<\/jats:italic>\u2010product could be converted to <jats:italic>E<\/jats:italic>\u2010product via a catalytic geometric isomerization of the <jats:italic>Z<\/jats:italic>\u2010alkene group. The silyl group in the products could provide a handle for downstream elaboration.<\/jats:p>","DOI":"10.1002\/anie.202311540","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:25:08Z","timestamp":1693891508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Copper\u2010Catalyzed Enantioselective and Regiodivergent Allylation of Ketones with Allenylsilanes"],"prefix":"10.1002","volume":"62","author":[{"given":"Menghua","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baihui","family":"Gong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Ti","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4865-820X","authenticated-orcid":false,"given":"Hequan","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy China Pharmaceutical University  Nanjing 210009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)85788-3"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.173"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.180"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.188"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100202"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201007719"},{"key":"e_1_2_3_8_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c08732"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506366"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol501304j"},{"key":"e_1_2_3_12_2","first-page":"2526","volume":"16","author":"Kim H. 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