{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:02:10Z","timestamp":1788778930536,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of methods for selective cleavage reactions of thermodynamically stable C\u2212C\/C=C bonds in a green manner is a challenging research field which is largely unexplored. Herein, we present a heterogeneous Fe\u2212N\u2212C catalyst with highly dispersed iron centers that allows for the oxidative C\u2212C\/C=C bond cleavage of amines, secondary alcohols, ketones, and olefins in the presence of air (O<jats:sub>2<\/jats:sub>) and water (H<jats:sub>2<\/jats:sub>O). Mechanistic studies reveal the presence of water to be essential for the performance of the Fe\u2212N\u2212C system, boosting the product yield from &lt;1\u2009% to &gt;90\u2009%. Combined spectroscopic characterizations and control experiments suggest the singlet <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> and hydroxide species generated from O<jats:sub>2<\/jats:sub> and H<jats:sub>2<\/jats:sub>O, respectively, take selectively part in the C\u2212C bond cleavage. The broad applicability (&gt;40 examples) even for complex drugs as well as high activity, selectivity, and durability under comparably mild conditions highlight this unique catalytic system.<\/jats:p>","DOI":"10.1002\/anie.202311913","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T06:42:24Z","timestamp":1694155344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Water\u2010Promoted Carbon\u2010Carbon Bond Cleavage Employing a Reusable Fe Single\u2010Atom Catalyst"],"prefix":"10.1002","volume":"62","author":[{"given":"Haifeng","family":"Qi","sequence":"first","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Mao","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabor","family":"Rabeah","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Qu","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials and Energy University of Electronic Science and Technology of China  Chengdu 611731 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zupeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"},{"name":"Analytical &amp; Testing Center College of Chemical Engineering Nanjing Forestry University  Nanjing 210037 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Bourriquen","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Xiamen University  Xiamen 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Junge","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-0965","authenticated-orcid":false,"given":"Matthias","family":"Beller","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Katalyse  Albert-Einstein-Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/9783527684625.ch17","volume-title":"Industrial Catalysis: A Practical Approach","author":"Hagen J.","year":"2015"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC03412E"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0001-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00629A"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00688B"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00306"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00158"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00797"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joule.2019.09.015"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2021.10.030"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00839-7"},{"key":"e_1_2_7_14_1","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05130"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000896"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12705"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307853"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17903-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110653"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00424"},{"key":"e_1_2_7_23_1","unstructured":"\u00a0"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add1267"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.checat.2021.11.013"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25118-0"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707171"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00386F"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2023.122937"},{"key":"e_1_2_7_30_1","unstructured":"\u00a0"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18941"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja207066z"},{"key":"e_1_2_7_33_1","unstructured":"\u00a0"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903019"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b03476"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2021.106333"},{"key":"e_1_2_7_37_1","first-page":"63","volume":"103","author":"Salonen M. S.","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"e_1_2_7_38_1","unstructured":"\u00a0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00576"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwy077"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-018-0090-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23429-w"},{"key":"e_1_2_7_43_1","unstructured":"\u00a0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802231"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC02105K"},{"key":"e_1_2_7_46_1","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08884"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41560-017-0078-8"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b02148"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC04480H"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c04467"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c08259"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602695"},{"key":"e_1_2_7_54_1","unstructured":"M.\u2005H. Qureshi The Njar\u00f0arson Group The University of Arizona Top 200 SMALL Molecule Drugs by Sales in 2021.https:\/\/njardarson.lab.arizona.edu\/content\/top-pharmaceuticals-poster."},{"key":"e_1_2_7_55_1","unstructured":"\u00a0"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202001025"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00155"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202311913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:19:21Z","timestamp":1753370361000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202311913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,19]]},"references-count":57,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2023,10,23]]}},"alternative-id":["10.1002\/anie.202311913"],"URL":"https:\/\/doi.org\/10.1002\/anie.202311913","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,19]]},"assertion":[{"value":"2023-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202311913"}}