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However, the important raw material NH<jats:sub>2<\/jats:sub>OH exhibits corrosive and unstable properties, leading to substantial energy consumption during storage and transportation. Herein, this work presents a novel method for directly synthesizing highly valuable pyridine oximes using in situ generated NH<jats:sub>2<\/jats:sub>OH from electrocatalytic NO reduction with well\u2010design nanofiber membranes (Al\u2010NFM) derived from NH<jats:sub>2<\/jats:sub>\u2010MIL\u201053(Al). Particularly, 2\u2010pyridinealdoxime, the precursor of antidote pralidoxime (2\u2010PAM) for nerve agents suffering from scarcity and high cost, was achieved with a Faraday efficiency up to 49.8\u2009% and a yield of 92.1\u2009%, attributing to the high selectivity of NH<jats:sub>2<\/jats:sub>OH production on Al\u2010NFM, further easily reacted with iodomethane to produce 2\u2010PAM. This study proposes a creative approach, having wide universality for synthesizing pyridine and other oximes with a range of functional groups, which not only facilitates the conversion of exhaust gas (NO) and waste water (NO<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>) into valuable chemicals especially NH<jats:sub>2<\/jats:sub>OH production and in situ utilization through electrochemistry, but also holds significant potential for synthesis of neuro detoxifying drugs to humanity security.<\/jats:p>","DOI":"10.1002\/anie.202312239","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T13:59:00Z","timestamp":1695218340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Electrocatalytic Synthesis of Pyridine Oximes using <i>in Situ<\/i> Generated NH<sub>2<\/sub>OH from NO species on Nanofiber Membranes Derived from NH<sub>2<\/sub>\u2010MIL\u201053(Al)"],"prefix":"10.1002","volume":"62","author":[{"given":"Runan","family":"Xiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisen","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Instrumental Analysis &amp; Research Center Sun Yat-Sen University  No.135, Xingangxi Road Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Guo","sequence":"additional","affiliation":[{"name":"Instrumental Analysis &amp; Research Center Sun Yat-Sen University  No.135, Xingangxi Road Guangzhou 510275 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-5591","authenticated-orcid":false,"given":"Guangqin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.03.026"},{"key":"e_1_2_7_2_1","unstructured":"\u00a0"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202002024"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(01)01345-1"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026181918567"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1916009"},{"key":"e_1_2_7_7_1","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107680409700113"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3007984"},{"key":"e_1_2_7_10_1","unstructured":"\u00a0"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122846"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03737"},{"key":"e_1_2_7_13_1","unstructured":"\u00a0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166305"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012374484-5.00065-1"},{"key":"e_1_2_7_16_2","first-page":"8","volume":"9","author":"Cherian R. 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