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This arylation reaction gave \u03b1\u2010(heteroaryl)\u2010\u03b1\u2010alkyl cyanoacetates in good to excellent enantioselectivities (up to 95\u2009% ee). A variety of functionalized (hetero)aryl and alkyl groups could be introduced to the quaternary center and therefore provided a valuable tool for preparing enantioenriched compounds with an all\u2010carbon quaternary center tethered with convertible functional groups. The size of both \u03b1\u2010alkyl and ester groups was proven as the key factor for asymmetric induction.<\/jats:p>","DOI":"10.1002\/anie.202312383","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T14:44:12Z","timestamp":1698072252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Copper\u2010Catalyzed Asymmetric Arylation of \u03b1\u2010Substituted Cyanoacetates Enabled by Chiral Amide Ligands"],"prefix":"10.1002","volume":"62","author":[{"given":"Rongxing","family":"Zhang","sequence":"first","affiliation":[{"name":"Chang-Kung Chuang Institute School of Chemistry and Molecular Engineering East China Normal University  500 Dongchuang Lu Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry of Ministry of Education Shanghai Key Laboratory of Rare Earth Functional Materials Shanghai Frontiers Science Center of Biomimetic Catalysis College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery Shenyang Pharmaceutical University Ministry of Education  Shenyang 110016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Lu Shanghai 200032 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