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However, the reported synthesis of centrally chiral azomethine imines relies on kinetic resolution, and the construction of axially chiral azomethine imines remains unexplored. Herein, we present the synthesis of axially chiral azomethine imines through copper\u2010 or chiral phosphoric acid catalyzed ring\u2010closure reactions of\n                    <jats:italic>N<\/jats:italic>\n                    \u2032\u2010(2\u2010alkynylbenzylidene)hydrazides, showcasing high efficiency, mild conditions, broad substrate scope, and excellent enantioselectivity. Furthermore, the biological evaluation revealed that the synthesized axially chiral azomethine imines effectively protect dorsal root ganglia (DRG) neurons by inhibiting apoptosis induced by oxaliplatin, offering a promising therapeutic approach for chemotherapy\u2010induced peripheral neuropathy (CIPN). Remarkably, the (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010 and (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010atropisomers displayed distinct neuroprotective activities, underscoring the significance of axial stereochemistry.\n                  <\/jats:p>","DOI":"10.1002\/anie.202312663","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T12:45:02Z","timestamp":1701348302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Catalytic Atroposelective Synthesis of Axially Chiral Azomethine Imines and Neuroprotective Activity Evaluation"],"prefix":"10.1002","volume":"63","author":[{"given":"Qian\u2010Qian","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahong","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Shenzhen Technology University  Shenzhen 518060 Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu 610041 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu 610041 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabo","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicines Macau University of Science and Technology  Macau 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3200-4682","authenticated-orcid":false,"given":"Bo","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Hospital of Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 611137 Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","unstructured":"E. 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