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This method involves the coupling of an N\u2010heterocyclic carbene\u2010derived ketyl radical and a secondary\n                    <jats:italic>sp<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>3<\/jats:italic>\n                    <\/jats:sup>\n                    \u2010carbon radical and allows access to chiral \u03b1\u2010aryl aliphatic ketones in moderate\u2010to\u2010good yields and enantioselectivities without any competitive epimerization. The utility of this protocol is highlighted by the late\u2010stage functionalization of various pharmaceutical compounds and is further demonstrated by the transformation of the enantioenriched products to biologically relevant molecules. Computational investigations reveal the N\u2010heterocyclic carbene controls the double\u2010facial selectivity of the ketyl radical and the alkyl radicals, respectively.\n                  <\/jats:p>","DOI":"10.1002\/anie.202312829","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T22:20:01Z","timestamp":1697494801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Light\u2010Driven Enantioselective Carbene\u2010Catalyzed Radical\u2010Radical Coupling"],"prefix":"10.1002","volume":"62","author":[{"given":"Seunghwan","family":"Byun","sequence":"first","affiliation":[{"name":"Department of Chemistry Northwestern University  Silverman Hall Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meemie U.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Northwestern University  Silverman Hall Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry R.","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Chemistry Oregon State University  153 Gilbert Hall Corvallis OR 97331 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Bay","sequence":"additional","affiliation":[{"name":"Department of Chemistry Northwestern University  Silverman Hall Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.\u2010Y.","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Chemistry Oregon State University  153 Gilbert Hall Corvallis OR 97331 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-3569","authenticated-orcid":false,"given":"Karl A.","family":"Scheidt","sequence":"additional","affiliation":[{"name":"Department of Chemistry Northwestern University  Silverman Hall Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"E.\u2005J. 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