{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:35:22Z","timestamp":1792794922229,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"50","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/001174"],"award-info":[{"award-number":["CRG\/2021\/001174"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,12,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>(Per)thionitrite (SNO<jats:sup>\u2212<\/jats:sup>\/SSNO<jats:sup>\u2212<\/jats:sup>) intermediates play vital roles in modulating nitric oxide (NO) and hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) dependent bio\u2010signalling processes. Whilst the previous preparations of such intermediates involved reactive H<jats:sub>2<\/jats:sub>S\/HS<jats:sup>\u2212<\/jats:sup> or sulfane sulfur (S<jats:sup>0<\/jats:sup>) species, the present report reveals that relatively stable thiocarbonyl compounds (such as carbon disulfide (CS<jats:sub>2<\/jats:sub>), thiocarbamate, thioacetic acid, and thioacetate) react with nitrite anion to yield SNO<jats:sup>\u2212<\/jats:sup>\/SSNO<jats:sup>\u2212<\/jats:sup>. For instance, the reaction of CS<jats:sub>2<\/jats:sub> and nitrite anion (NO<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>) under ambient condition affords CO<jats:sub>2<\/jats:sub> and SNO<jats:sup>\u2212<\/jats:sup>\/SSNO<jats:sup>\u2212<\/jats:sup>. A detailed investigation involving UV\/Vis, FTIR, HRMS, and multinuclear NMR studies confirm the formation of SNO<jats:sup>\u2212<\/jats:sup>\/SSNO<jats:sup>\u2212<\/jats:sup>, which are proposed to form through an initial nucleophilic attack by nitrite anion followed by a transnitrosation step. Notably, reactions of CS<jats:sub>2<\/jats:sub> and nitrite in the presence of thiol RSH show the formation of organic polysulfides R\u2010S<jats:sub>n<\/jats:sub>\u2010R, thereby illustrating that the thiocarbonyls are capable of influencing the pool of bioavailable sulfane sulfurs. Furthermore, the availability of both NO<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> and thiocarbonyl motifs in the biological context hints at their synergistic metal\u2010free activations leading to the generation of NO gas and various reactive sulfur species via SNO<jats:sup>\u2212<\/jats:sup>\/SSNO<jats:sup>\u2212<\/jats:sup>.<\/jats:p>","DOI":"10.1002\/anie.202313187","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T19:34:30Z","timestamp":1697744070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synergistic Activation of Nitrite and Thiocarbonyl Compounds Affords NO and Sulfane Sulfur via (Per)thionitrite (SNO<sup>\u2212<\/sup>\/SSNO<sup>\u2212<\/sup>)"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-8834","authenticated-orcid":false,"given":"Gayathri","family":"Kolliyedath","sequence":"first","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER-Tvm) Thiruvananthapuram  695551 Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-2148","authenticated-orcid":false,"given":"Tuhin","family":"Sahana","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER-Tvm) Thiruvananthapuram  695551 Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4439-9355","authenticated-orcid":false,"given":"Silpa Mary","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER-Tvm) Thiruvananthapuram  695551 Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3533-3206","authenticated-orcid":false,"given":"Subrata","family":"Kundu","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER-Tvm) Thiruvananthapuram  695551 Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6909"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.005"},{"key":"e_1_2_3_3_1","first-page":"227","volume-title":"Advances in Inorganic Chemistry, Vol. 7","author":"Marcolongo J. 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