{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:29:49Z","timestamp":1786976989844,"version":"build-2736575974"},"reference-count":102,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1500200"],"award-info":[{"award-number":["2021YFA1500200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171277, 22101291, 21821002, 22201062"],"award-info":[{"award-number":["22171277, 22101291, 21821002, 22201062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420111"],"award-info":[{"award-number":["222300420111"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The precise control of the regioselectivity in the transition metal\u2010catalyzed migratory hydrofunctionalization of alkenes remains a big challenge. With a transient ketimine directing group, the nickel\u2010catalyzed migratory\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010selective hydroarylation and hydroalkenylation of alkenyl ketones has been realized with aryl boronic acids using alkyl halide as the mild hydride source for the first time. The key to this success is the use of a diphosphine ligand, which is capable of the generation of a Ni(II)\u2010H species in the presence of alkyl bromide, and enabling the efficient migratory insertion of alkene into Ni(II)\u2010H species and the sequent rapid chain walking process. The present approach diminishes organosilanes reductant, tolerates a wide array of complex functionalities with excellent regioselective control. Moreover, this catalytic system could also be applied to the migratory hydroarylation of alkenyl azahetereoarenes, thus providing a general approach for the preparation of 1,2\u2010aryl heteroaryl motifs with wide potential applications in pharmaceutical discovery.\n                  <\/jats:p>","DOI":"10.1002\/anie.202313336","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T05:07:00Z","timestamp":1700543220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Diphosphine Ligand\u2010Enabled Nickel\u2010Catalyzed Chelate\u2010Assisted Inner\u2010Selective Migratory Hydroarylation of Alkenes"],"prefix":"10.1002","volume":"63","author":[{"given":"Hua\u2010Dong","family":"He","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 P. R. China"},{"name":"State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry  CAS 345 Lingling Road Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Chitrakar","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry  CAS 345 Lingling Road Shanghai 200032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 P. R. China"},{"name":"State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry  CAS 345 Lingling Road Shanghai 200032 P. R. 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