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Heterogeneous catalysts for this chemistry remain largely unexplored despite the advantages they offer in terms of ease of separation and reuse of catalysts. Herein, we report the development of heterogeneous chiral Rh catalysts for continuous\u2010flow enantioselective hydroacylations. Heterogeneous catalysts could be prepared simply by mixing supports and Rh complexes. The prepared catalysts exhibited excellent activity and enantioselectivity affording optically active ketones in quantitative yields with 99\u2009% ee's. Under the optimized reaction conditions, a turnover number &gt;300 was achieved without the leaching of Rh species. The catalysts exhibited a wide substrate scope and in sequential\u2010flow reactions with other heterogeneous catalysts, the syntheses of biologically active molecules and functional materials were demonstrated.<\/jats:p>","DOI":"10.1002\/anie.202313778","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T05:42:06Z","timestamp":1700718126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Continuous\u2010Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts"],"prefix":"10.1002","volume":"63","author":[{"given":"Yuki","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Science The University of Tokyo  7-3-1, Hongo, Bunkyo-ku Tokyo 113-0033 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