{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:44:31Z","timestamp":1790858671620,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","award":["Liebig Fellowship"],"award-info":[{"award-number":["Liebig Fellowship"]}],"id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["497336511"],"award-info":[{"award-number":["497336511"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["527736106"],"award-info":[{"award-number":["527736106"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a mild, catalytic method for the intermolecular reductive coupling of feedstock dienes and styrenes with ketones. Our conditions allow concomitant formation of a cobalt hydride species and single\u2010electron reduction of ketones. Subsequent selective hydrogen\u2010atom transfer from the cobalt hydride generates an allylic radical which can selectively couple with the persistent radical\u2010anion of the ketone. This radical\u2010radical coupling negates unfavourable steric interactions of ionic pathways and avoids the unstable alkoxy radical of previous radical olefin\u2010carbonyl couplings, which were limited, as a result, to aldehydes. Applications of this novel and straightforward approach include the efficient synthesis of drug molecules, key intermediates in drug synthesis and site\u2010selective late\u2010stage functionalisation.<\/jats:p>","DOI":"10.1002\/anie.202314870","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T08:15:57Z","timestamp":1699604157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Dual\u2010Catalysed Intermolecular Reductive Coupling of Dienes and Ketones**"],"prefix":"10.1002","volume":"63","author":[{"given":"Victor J.","family":"Mayerhofer","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Lippolis","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-5674","authenticated-orcid":false,"given":"Christopher J.","family":"Teskey","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry TU Braunschweig  Hagenring 30 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3md00088e"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020050h"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200802938"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202101890"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00827-2"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/B414322A"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol800159w"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja801213x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2046028"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219274"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja311208a"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sc22051f"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol702543m"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol901527b"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA00853B"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7720"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12271"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13907"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b01784"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b00979"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3075049"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4087193"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00334"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00337"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04112B"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304882"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709659"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b03794"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b04459"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c03081"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203286"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr50026a002"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00183a035"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo990652"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c004166a"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11699"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05109"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310639"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20872-z"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2021.153047"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c00527"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04595-3"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08278"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c04970"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214433"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202301484"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02128"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110178"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05017"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c05557"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02436"},{"key":"e_1_2_3_52_1","doi-asserted-by":"crossref","unstructured":"S.\u2005H. Park G. Bae A. Choi S. Shin K. Shin C.\u2005H. Choi H. Kim J. Am. Chem. Soc.2023 https:\/\/doi.org\/10.1021\/jacs.3c03172.","DOI":"10.1021\/jacs.3c03172"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05428"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b08086"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00799"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903726"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03692"},{"key":"e_1_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706724"},{"key":"e_1_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201500734"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07271"},{"key":"e_1_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202000751"},{"key":"e_1_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b02204"},{"key":"e_1_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00284a041"},{"key":"e_1_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258232"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915762"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05994"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC02356C"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC01966C"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1379304"},{"key":"e_1_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c02272"},{"key":"e_1_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00131"},{"key":"e_1_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00505a024"},{"key":"e_1_2_3_73_1","doi-asserted-by":"crossref","unstructured":"J. Qin M. Barday S. Jana N. Sanosa I. Funes-Ardoiz C. Teskey ChemRxiv preprint2023 https:\/\/doi.org\/10.26434\/chemrxiv-2023-3rshq.","DOI":"10.26434\/chemrxiv-2023-3rshq"},{"key":"e_1_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03141"},{"key":"e_1_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00300A"},{"key":"e_1_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3076988"},{"key":"e_1_2_3_77_1","first-page":"1597","volume":"49","author":"Gao H.-S.","year":"2017","journal-title":"Synthesis"},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00303"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05211-0"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115348"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202314870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T08:47:33Z","timestamp":1738572453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202314870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,8]]},"references-count":80,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,8]]}},"alternative-id":["10.1002\/anie.202314870"],"URL":"https:\/\/doi.org\/10.1002\/anie.202314870","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2023-43tzg","asserted-by":"object"},{"id-type":"doi","id":"10.26434\/chemrxiv-2023-43tzg-v2","asserted-by":"object"}]},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,8]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202314870"}}