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Thus, when an acyl chloride and an \u03b1\u2010amido\u2010containing redox\u2010active ester are exposed to a nickel catalyst, chiral ligand, and metal reductant, \u03b1\u2010amido ketones are produced in good yield and high ee. The reaction exhibits broad substrate scope, can be easily scaled up, and is applied to dramatically simplify the synthesis of several known structures.<\/jats:p>","DOI":"10.1002\/anie.202315203","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T15:00:21Z","timestamp":1699455621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Nickel\u2010Catalyzed Enantioselective Decarboxylative Acylation: Rapid, Modular Access to \u03b1\u2010Amino Ketones**"],"prefix":"10.1002","volume":"62","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  10550 North Torrey Pines Road La Jolla CA 92037 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-9053","authenticated-orcid":false,"given":"Phil 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