{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:01:55Z","timestamp":1779080515495,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Catalytic asymmetric allylation of ketones under proton\u2010transfer conditions is a challenging issue due to the limited pronucleophiles and the electrophilic inertness of ketones. Herein, a copper(I)\u2010catalyzed asymmetric allylation of ketones with 2\u2010aza\u20101,4\u2010dienes (<jats:italic>N<\/jats:italic>\u2010allyl\u20101,1\u2010diphenylmethanimines) is disclosed, which affords a series of functionalized homoallyl tertiary alcohols in high to excellent enantioselectivity. Interestingly, <jats:italic>N<\/jats:italic>\u2010allyl\u20101,1\u2010diphenylmethanimines work as synthetic equivalents of propanals. Upon the acidic workup, a formal asymmetric \u03b2\u2010addition of propanals to ketones is achieved. An investigation on KIE effect indicates that the deprotonation of <jats:italic>N<\/jats:italic>\u2010allyl\u20101,1\u2010diphenylmethanimines is the rate\u2010determining step, which generates nucleophilic allyl copper(I) species. Finally, the synthetic utility of the present method is demonstrated by the asymmetric synthesis of (<jats:italic>R<\/jats:italic>)\u2010boivinianin A and (<jats:italic>R<\/jats:italic>)\u2010gossonorol.<\/jats:p>","DOI":"10.1002\/anie.202315293","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T12:15:30Z","timestamp":1699877730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Copper(I)\u2010Catalyzed Asymmetric Allylation of Ketones with 2\u2010Aza\u20101,4\u2010Dienes"],"prefix":"10.1002","volume":"63","author":[{"given":"Zhi\u2010Zhou","family":"Pan","sequence":"first","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Heng","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-5198","authenticated-orcid":false,"given":"Liang","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and 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