{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:28:53Z","timestamp":1786976933893,"version":"build-2736575974"},"reference-count":98,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171027"],"award-info":[{"award-number":["22171027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["2212009"],"award-info":[{"award-number":["2212009"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2233300007"],"award-info":[{"award-number":["2233300007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Planar\u2010chiral cyclophanes have received increasing attention for drug discovery and catalyst design. However, the catalytically asymmetric synthesis of planar\u2010chiral cyclophanes has been a longstanding challenge. We describe the first Pd(II)\u2010catalyzed enantioselective C\u2212H olefination of prochiral cyclophanes. The low rotational barrier of less hindered benzene ring in the substrates allows the reaction to proceed through a dynamic kinetic resolution. This approach exhibits broad substrate scope, providing the planar\u2010chiral cyclophanes in high yields (up to 99\u2009%) with excellent enantioselectivities (up to &gt;99\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    ). The\n                    <jats:italic>ansa<\/jats:italic>\n                    chain length scope studies reveal that the chirality of the cyclophanes arises from the bond rotation constraint of the benzene ring around the macrocycle plane, rather than the C\u2212N axis. The C\u2212H activation approach is also applicable to the late\u2010stage modification of bioactive molecules and pharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/anie.202315603","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T23:16:27Z","timestamp":1698966987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Palladium\u2010Catalyzed Enantioselective C\u2212H Olefination to Access Planar\u2010Chiral Cyclophanes by Dynamic Kinetic Resolution"],"prefix":"10.1002","volume":"62","author":[{"given":"Ziyang","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University  Beijing 100875 (P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University  Beijing 100875 (P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University  Beijing 100875 (P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-0443","authenticated-orcid":false,"given":"Changgui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University  Beijing 100875 (P. R. 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selected studies oncis\/transrotamers of amides see:"},{"key":"e_1_2_3_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2012.05.025"},{"key":"e_1_2_3_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja312532x"},{"key":"e_1_2_3_90_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00205"},{"key":"e_1_2_3_91_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.9b04555"},{"key":"e_1_2_3_92_1","unstructured":"Thecis\/transamide isomerism and exchange correlations of1\u2009aand3\u2009aawere observed in the variable temperature1H NMR and 2D EXSY respectively."},{"key":"e_1_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC01130H"},{"key":"e_1_2_3_94_1","unstructured":"Deposition number2281385 (for3\u2009aa)contains the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum KarlsruheAccess Structures service."},{"key":"e_1_2_3_95_1","unstructured":"For selected reviews on KIE studies see:"},{"key":"e_1_2_3_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001018"},{"key":"e_1_2_3_97_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100436k"},{"key":"e_1_2_3_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar020148i"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202315603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T12:17:42Z","timestamp":1712060262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202315603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":98,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2023,12,18]]}},"alternative-id":["10.1002\/anie.202315603"],"URL":"https:\/\/doi.org\/10.1002\/anie.202315603","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]},"assertion":[{"value":"2023-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202315603"}}