{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:31:48Z","timestamp":1780493508657,"version":"3.54.1"},"reference-count":72,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no. 21871101"],"award-info":[{"award-number":["no. 21871101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015939","name":"Hubei Provincial Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["No. BCMM202203"],"award-info":[{"award-number":["No. BCMM202203"]}],"id":[{"id":"10.13039\/501100015939","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Artificial molecular muscles are highly attractive in the field of molecular machinery due to their unique properties of contraction and stretching motion. However, the synthesis of molecular muscles poses formidable challenges as it is hindered by undesirable yields and poor selectivity. Herein, we present a procedure for the dynamic assembly of foldaxane\u2010based [<jats:italic>c<\/jats:italic>2]daisy chains, wherein the hermaphroditic sequences consisting of aromatic helices and peptide rods are interlocked through inter\u2010strand hydrogen\u2010bonding interactions. The binding complementarity facilitates a selective and efficient assembly of [<jats:italic>c<\/jats:italic>2]daisy chain structures, inhibiting the creation of by\u2010products. Introducing multiple recognition sites confers the system with contraction and stretching motion actuated by chemical stimuli. The rate of this muscle\u2010like motion is calculated to be 0.8\u2005s<jats:sup>\u22121<\/jats:sup>, which is 10<jats:sup>7<\/jats:sup>\u2005times faster than that of complex dissociation.<\/jats:p>","DOI":"10.1002\/anie.202315668","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T22:23:45Z","timestamp":1707776625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Foldaxane\u2010Based Switchable [<i>c<\/i>2]Daisy Chains"],"prefix":"10.1002","volume":"63","author":[{"given":"Sibei","family":"Liao","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical Biology Tsinghua Shenzhen International Graduate School Tsinghua University  518055 Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanzhu","family":"Li","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-2268","authenticated-orcid":false,"given":"Quan","family":"Gan","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Bioinorganic Chemistry &amp; Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology  Luoyu Road No. 1037 430074 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar0001766"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00146"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905250"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00291"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00340"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c01234"},{"key":"e_1_2_3_8_1","unstructured":"\u00a0"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01479a015"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00099a095"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4cs00029c"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao1377"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12303"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02029"},{"key":"e_1_2_3_15_1","unstructured":"\u00a0"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229753"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0040-9"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214296"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05305-9"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305767"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310643"},{"key":"e_1_2_3_22_1","unstructured":"\u00a0"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980518)37:9<1294::AID-ANIE1294>3.0.CO;2-F"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol9913587"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol203062w"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35217F"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.2c00711"},{"key":"e_1_2_3_28_1","unstructured":"\u00a0"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500138u"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.019.20180023"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3284::AID-ANIE3284>3.0.CO;2-7"},{"key":"e_1_2_3_32_1","unstructured":"\u00a0"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/b809014a"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201000169"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11351"},{"key":"e_1_2_3_36_1","unstructured":"\u00a0"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol801390h"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803036"},{"key":"e_1_2_3_39_1","unstructured":"\u00a0"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol063078e"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo101234u"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20728a"},{"key":"e_1_2_3_43_2","doi-asserted-by":"crossref","unstructured":"Y. Yao P. Zhang D. Zhou Z. Lai S. Li F. Huang Z. Zhang Chin. Chem. Lett.2023 doi:https:\/\/doi.org\/10.1016\/j.cclet.2023.108712.","DOI":"10.1016\/j.cclet.2023.108712"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja500675y"},{"key":"e_1_2_3_45_1","unstructured":"\u00a0"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20072d"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2709"},{"key":"e_1_2_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2608"},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02475"},{"key":"e_1_2_3_50_1","unstructured":"\u00a0"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9077655"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob42044b"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15220C"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00050"},{"key":"e_1_2_3_55_1","unstructured":"\u00a0"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200143"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201101697"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b04884"},{"key":"e_1_2_3_59_1","unstructured":"\u00a0"},{"key":"e_1_2_3_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja3064364"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.15"},{"key":"e_1_2_3_62_1","unstructured":"\u00a0"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508611"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813125"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202100349"},{"key":"e_1_2_3_66_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC03066G"},{"key":"e_1_2_3_67_1","unstructured":"Deposition numbers 2289630 (1); 2289629 (2) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja971224t"},{"key":"e_1_2_3_69_1","unstructured":"\u00a0"},{"key":"e_1_2_3_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja036665t"},{"key":"e_1_2_3_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b00941"},{"key":"e_1_2_3_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07143"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202315668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T13:48:39Z","timestamp":1755611319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202315668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":72,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.1002\/anie.202315668"],"URL":"https:\/\/doi.org\/10.1002\/anie.202315668","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]},"assertion":[{"value":"2023-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202315668"}}