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We demonstrate the transmutation of four archetypal solution\u2010state photocatalysis reactions to a solvent\u2010minimized environment driven by the combined actions of milling, light, and photocatalysts. The chlorosulfonylation of alkenes and the pinacol coupling of aldehydes and ketones were conducted under solvent\u2010free conditions with competitive or superior efficiencies to their solution\u2010state analogues. Furthermore, decarboxylative alkylations are shown to function efficiently under solvent\u2010minimized conditions, while the photoinduced energy transfer promoted [2+2] cycloaddition of chalcone experiences a significant initial rate enhancement over its solution\u2010state variant. This work serves as a platform for future discoveries in an underexplored field: validating that solvent\u2010minimized photocatalysis is not only generalizable and competitive with solution\u2010state photocatalysis, but can also offer valuable advantages.<\/jats:p>","DOI":"10.1002\/anie.202316169","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T02:29:42Z","timestamp":1706063382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mechanophotocatalysis: A Generalizable Approach to Solvent\u2010minimized Photocatalytic Reactions for Organic Synthesis"],"prefix":"10.1002","volume":"63","author":[{"given":"Francis","family":"Millward","sequence":"first","affiliation":[{"name":"Organic Semiconductor Centre EaStCHEM School of Chemistry University of St. Andrews  St. Andrews KY16 9ST United 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