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Nevertheless, the rate\u2010determining step in Fenton chemistry, which involves the transition of a high\u2010valence metallic center (Fe<jats:sup>III<\/jats:sup>) to a Fenton\u2010active low\u2010valence metallic center (Fe<jats:sup>II<\/jats:sup>), has hindered advances in nanocatalyst\u2010based therapeutics. In this study, we constructed mesoporous single iron atomic nanocatalysts (mSAFe NCs) by employing catechols from dopamine to coordinate and isolate single iron atoms. The catechols also serve as reductive ligands, generating a field\u2010effect\u2010based cocatalytic system that instantly reduces Fe<jats:sup>III<\/jats:sup> species to Fe<jats:sup>II<\/jats:sup> species within the mSAFe NCs. 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