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Installing various substituents through pyridine C\u2212H bond functionalization is significant for new drug design and discovery. Developments of late\u2010stage functionalization reactions enrich the strategies for selective functionalization of pyridines. However, late\u2010stage C\u2212H carboxylation of pyridines is a long\u2010standing challenge, especially selectively carboxylation with CO<jats:sub>2<\/jats:sub> on pyridine motifs. Herein, we describe a practical method for C4\u2212H carboxylation of pyridines via one\u2010pot C\u2212H phosphination and copper\u2010catalyzed carboxylation of the resulted phosphonium salts with CO<jats:sub>2<\/jats:sub>. The reaction is conducted under mild conditions and compatible with multiple active groups and several pyridine drugs, providing diverse valuable isonicotinic acid compounds, demonstrating the application potential of this strategy.<\/jats:p>","DOI":"10.1002\/anie.202318572","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T22:30:25Z","timestamp":1706913025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Copper\u2010Catalyzed C4\u2010selective Carboxylation of Pyridines with CO<sub>2<\/sub> via Pyridylphosphonium Salts"],"prefix":"10.1002","volume":"63","author":[{"given":"Shibiao","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Elemento-Organic Chemistry and Frontiers Science Center for New Organic Matter College of Chemistry Nankai University  Tianjin 30007 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