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Herein, we developed an approach for the selective coupling of methanol and aliphatic primary amines, without high\u2010pressure hydrogen, using a manganese\u2010based catalyst. Remarkably, up to 98\u2009% yields with broad substrate scope were achieved at low catalyst loadings. Notably, due to the weak base\u2010catalyzed alcoholysis of formamide intermediates, our novel protocol not only obviates the addition of high\u2010pressure H<jats:sub>2<\/jats:sub> but also prevents side secondary <jats:italic>N<\/jats:italic>\u2010methylation, supported by control experiments and density functional theory calculations.<\/jats:p>","DOI":"10.1002\/anie.202318763","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T10:19:49Z","timestamp":1706782789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Manganese\u2010Catalyzed Mono\u2010<i>N<\/i>\u2010Methylation of Aliphatic Primary Amines without the Requirement of External High\u2010Hydrogen Pressure"],"prefix":"10.1002","volume":"63","author":[{"given":"Jiale","family":"Ji","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  2005 Songhu Road Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghao","family":"Huo","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  2005 Songhu Road Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowen","family":"Dai","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  2005 Songhu Road Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  155 Yangqiao West Road Fuzhou 350002 China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-7889","authenticated-orcid":false,"given":"Tao","family":"Tu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of Chemistry Fudan University  2005 Songhu Road Shanghai 200438 China"},{"name":"State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences  354 Fenglin Road Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00544H"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.08.031"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205674"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr200060g"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201803642"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/1385272823666190823114547"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201400984"},{"key":"e_1_2_8_10_1","unstructured":"\u00a0"},{"key":"e_1_2_8_11_2","author":"He M.","year":"2023","journal-title":"Nat. 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