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Here, we disclosed an unprecedented enantioselective C\u2212H carbonylation catalyzed by inexpensive and readily available cobalt(II) salt. The reactions proceed efficiently through desymmetrization, kinetic resolution, and parallel kinetic resolution, affording a broad range of chiral isoindolinones in good yields with excellent enantioselectivities (up to 92\u2009% yield and 99\u2009% ee). The synthetic potential of this method was demonstrated by asymmetric synthesis of biological active compounds, such as (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010PD172938 and (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010Pazinaclone. The resulting chiral isoindolinones also serve as chiral ligands in cobalt\u2010catalyzed enantioselective C\u2212H annulation with alkynes to construct phosphorus stereocenter.\n                  <\/jats:p>","DOI":"10.1002\/anie.202318803","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T07:30:16Z","timestamp":1704958216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Cobalt\u2010Catalyzed Enantioselective C\u2212H Carbonylation towards Chiral Isoindolinones"],"prefix":"10.1002","volume":"63","author":[{"given":"Ming\u2010Ya","family":"Teng","sequence":"first","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan\u2010Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-955X","authenticated-orcid":false,"given":"Bing\u2010Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University  Hangzhou 310027 China"},{"name":"College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education Hangzhou Normal University  Hangzhou 311121, Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02748"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c00682"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c01087"},{"key":"e_1_2_3_5_1","unstructured":"\u00a0"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00252-2"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.01.080"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.07.054"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.55.1682"},{"key":"e_1_2_3_10_2","unstructured":"A.Bjoere J.Bostroem O.Davidsson H.Emtenaes U.Gran T.Iliefski J.Kajanus R.Olsson L.Sandberg G.Strandlund J.Sundell Z.-Q.Yuan WO2008008022\u2005A1 2008;"},{"key":"e_1_2_3_11_2","unstructured":"J.Varghese M.Maillard B.Jagodzinska J. 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