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However, real\u2010time monitoring the rapid chemical changes during SD to probe the molecular mechanism remains a great challenge. We develop a potentiometric dual\u2010channel microsensor for simultaneous monitoring of H\n                    <jats:sub>2<\/jats:sub>\n                    S and pH featuring excellent selectivity and spatiotemporal resolution. Using this microsensor we first observe real time changes of H\n                    <jats:sub>2<\/jats:sub>\n                    S and pH in the rat brain induced by SD. This changes of H\n                    <jats:sub>2<\/jats:sub>\n                    S are completely suppressed when the rat pre\u2010treats with aminooxyacetic acid (AOAA), a blocker to inhibit the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing enzyme, indicating H\n                    <jats:sub>2<\/jats:sub>\n                    S fluctuation might be related to enzyme\u2010dependent pathway during SD and less pH\u2010dependent. This study provides a new perspective for studying the function of H\n                    <jats:sub>2<\/jats:sub>\n                    S and the molecular basis of SD\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.202318973","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T22:11:30Z","timestamp":1706220690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Potentiometric Dual\u2010Channel Microsensor Reveals that Fluctuation of H\n                    <sub>2<\/sub>\n                    S is Less pH\u2010Dependent During Spreading Depolarization in the Rat Brain"],"prefix":"10.1002","volume":"63","author":[{"given":"Rantong","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"},{"name":"College of Petroleum and Environment Engineering Yan'an University  Shaanxi Yan'an 716000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyue","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-6025","authenticated-orcid":false,"given":"Meining","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqun","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.4476"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2333"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2014"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3770"},{"key":"e_1_2_7_6_1","unstructured":"\u00a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09011"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201901035"},{"key":"e_1_2_7_8_3","first-page":"6618","volume":"131","year":"2019","journal-title":"Angew. 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