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However, the precise control of oligomerization degree is still challenging because the starting materials and intermediates have similar reactivities. Here, we demonstrate the selective synthesis of a methylene\u2010bridged arene trimer using the confined cavity of a coordination cage. The limited space of the cavity prevents unregulated polymerization. The confinement effect for the kinetic protection is also demonstrated by the subsequent site\u2010selective iodination of the trimer product within the cage.<\/jats:p>","DOI":"10.1002\/anie.202319140","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T11:46:47Z","timestamp":1703072807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Selective Synthesis and Functionalization of an Acyclic Methylene\u2010Bridged\u2010Arene Trimer in a Cage"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5552-8027","authenticated-orcid":false,"given":"Hiroki","family":"Takezawa","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry School of Engineering The University of Tokyo Mitsui Link Lab Kashiwanoha 1, FS CREATION  6-6-2 Kashiwanoha Kashiwa Chiba 227-0882 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7071-4524","authenticated-orcid":false,"given":"Kenta","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry School of Engineering The University of Tokyo Mitsui Link Lab Kashiwanoha 1, FS CREATION  6-6-2 Kashiwanoha Kashiwa Chiba 227-0882 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6105-7340","authenticated-orcid":false,"given":"Makoto","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry School of Engineering The University of Tokyo Mitsui Link Lab Kashiwanoha 1, FS CREATION  6-6-2 Kashiwanoha Kashiwa Chiba 227-0882 Japan"},{"name":"Division of Advanced Molecular Science, Insititute for Molecular Science (IMS)  5-1 Higashiyama, Myodaiji Okazaki Aichi 444-8787 Japan"},{"name":"The University of Tokyo Institutes for Advanced Study (UTIAS) The University of Tokyo  7-3-1 Hongo Bunkyo-ku Tokyo 113-8654 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2004.01.004"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2012.07.003"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA06487G"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c01153"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199507131"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr960385x"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/B508530F"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC10150A"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00765"},{"key":"e_1_2_3_12_1","unstructured":"\u00a0"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-013-9332-2"},{"key":"e_1_2_3_14_2","first-page":"43","author":"Bulle S.","year":"2016","journal-title":"Pharmacogn. 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