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Novel prophylactic and therapeutic interventions are urgently needed since the current chemotherapy displays limited efficiency in AE treatment. Bioengineered nano cellular membrane vesicles are widely used for displaying the native conformational epitope peptides because of their unique structure and biocompatibility. In this study, four T\u2010cells and four B\u2010cells dominant epitope peptides of <jats:italic>E.\u2005multilocularis<\/jats:italic> with high immunogenicity were engineered into the Vero cell surface to construct a membrane vesicle nanovaccine for the treatment of AE. The results showed that the nanovesicle vaccine can efficiently activate dendritic cells, induce specific T\/B cells to form a mutually activated circuit, and inhibit <jats:italic>E.\u2005multilocularis<\/jats:italic> infection. This study presents for the first time a nanovaccine strategy that can completely eliminate the burden of <jats:italic>E.\u2005multilocularis<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/anie.202319489","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T22:30:04Z","timestamp":1706913004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Bioengineered Nanovesicle Vaccine Boosts T\u2010B cell Interaction for Immunotherapy of <i>Echinococcus multilocularis<\/i>"],"prefix":"10.1002","volume":"63","author":[{"given":"Xiaoyu","family":"An","sequence":"first","affiliation":[{"name":"State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory National Innovation Platform for Industry-Education Integration in Vaccine Research School of Public Health Xiamen University  4221 Xianganan Road, Xiang 'an 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