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In this direction, the reaction of\n                    <jats:italic>N\u2010<\/jats:italic>\n                    heteroaryl sulfur(IV) and\n                    <jats:italic>N\u2010<\/jats:italic>\n                    heteroaryl phosphorus(V) compounds has been well studied. However, the ligand coupling of sulfur(VI) is still underdeveloped and the reaction of alkyl\n                    <jats:italic>N\u2010<\/jats:italic>\n                    heteroarylsulfones is still elusive, which does not match the high status of sulfones as the chemical chameleons in organic synthesis. Here we present a ligand coupling\u2010enabled formal SO\n                    <jats:sub>2<\/jats:sub>\n                    extrusion of fluoroalkyl 2\u2010azaheteroarylsulfones under the promotion of Grignard reagents, which not only enriches the chemistry of sulfones, but also provides a novel and practical synthetic tool towards\n                    <jats:italic>N\u2010<\/jats:italic>\n                    heteroaromatic fluoroalkylation.\n                  <\/jats:p>","DOI":"10.1002\/anie.202401091","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T02:33:45Z","timestamp":1710556425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<i>N<\/i>\n                    \u2010Heteroaromatic Fluoroalkylation through Ligand Coupling Reaction of Sulfones"],"prefix":"10.1002","volume":"63","author":[{"given":"Huamin","family":"Liang","sequence":"first","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"},{"name":"School of Physical Science and Technology ShanghaiTech University  100 Haike Road Shanghai 201210 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  345 Lingling Road Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy 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