{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:55:34Z","timestamp":1793505334982,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM113030"],"award-info":[{"award-number":["R01GM113030"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1531189"],"award-info":[{"award-number":["CHE-1531189"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is an important reactive sulfur species that is involved in many biological functions, and H\n                    <jats:sub>2<\/jats:sub>\n                    S imbalances have been indicated as a potential biomarker for various diseases. Different H\n                    <jats:sub>2<\/jats:sub>\n                    S donors have been developed to deliver H\n                    <jats:sub>2<\/jats:sub>\n                    S directly to biological systems, but few reports include donors with optical responses that allow for tracking of H\n                    <jats:sub>2<\/jats:sub>\n                    S release. Moreover, donor systems that use the same chemistry to deliver H\n                    <jats:sub>2<\/jats:sub>\n                    S across a palette of fluorescent responses remain lacking. Here we report five thiol\u2010activated fluorescence turn\u2010on COS\/H\n                    <jats:sub>2<\/jats:sub>\n                    S donors that utilize blue, yellow, orange, red, and near infrared\u2010emitting dyes functionalized with an H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing sulfenyl thiocarbonate scaffold. Upon treatment with thiols, each donor provides a fluorescence turn\u2010on response (3\u2013310\u2010fold) and high H\n                    <jats:sub>2<\/jats:sub>\n                    S release efficiencies (&gt;60\u2009%). Using combined electrode and fluorescence experiments, we directly correlate the measured H\n                    <jats:sub>2<\/jats:sub>\n                    S release with the fluorescence response. All donors are biocompatible and release H\n                    <jats:sub>2<\/jats:sub>\n                    S in live cell environments. In addition, we demonstrate that the NIR donor allows for imaging H\n                    <jats:sub>2<\/jats:sub>\n                    S release in live rats via subcutaneous injection of the donor loaded into an alginate gel, which to the best of our knowledge is the first in vivo tracking of H\n                    <jats:sub>2<\/jats:sub>\n                    S release from a fluorogenic donor in non\u2010transparent organisms.\n                  <\/jats:p>","DOI":"10.1002\/anie.202402353","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T12:35:39Z","timestamp":1712320539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["An Expanded Palette of Fluorescent COS\/H\n                    <sub>2<\/sub>\n                    S\u2010Releasing Donors for H\n                    <sub>2<\/sub>\n                    S Delivery, Detection, and In Vivo Application"],"prefix":"10.1002","volume":"63","author":[{"given":"Kaylin G.","family":"Fosnacht","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology University of Oregon  Eugene OR, 97403 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Dorogin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology University of Oregon  Eugene OR, 97403 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payton M.","family":"Jefferis","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology University of Oregon  Eugene OR, 97403 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian H.","family":"Hettiaratchi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology University of Oregon  Eugene OR, 97403 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-653X","authenticated-orcid":false,"given":"Michael D.","family":"Pluth","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Materials Science Institute, Knight Campus for Accelerating Scientific Impact, Institute of Molecular Biology University of Oregon  Eugene OR, 97403 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603768295249"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00024.2015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2009.03.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00377.2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7058"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115634109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2898"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01119.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.21.6008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2894"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.10.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00362K"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7841"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.11.014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.10.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.05.018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00298A"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.3c00427"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00683"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03780"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05930K"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1AY01783G"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1AN01809D"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112734"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.120243"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c05081"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0AN00371A"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.9b01093"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC02323B"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.133131"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02259"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.011"},{"key":"e_1_2_8_33_1","first-page":"476","volume":"1","author":"Zhao X.","year":"2022","journal-title":"Acta Inform. Med."},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c00230"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC02053C"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC01172A"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02425F"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC00613K"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC05200J"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja1014103"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02346"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2020.108901"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja305802v"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34307-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.3.965"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/1010-6030(89)87054-6"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0760385TESIOR2.0.CO2"},{"key":"e_1_2_8_48_1","unstructured":"We note that the measured H2S release for this donor slightly exceeds the expected maximum which we attribute to changes in electrode response due to organic components formed during the reaction."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b03336"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)69917-X"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00805"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202200426"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/anie.202402353","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202402353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:13:27Z","timestamp":1721970807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202402353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,3]]},"references-count":52,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,6,10]]}},"alternative-id":["10.1002\/anie.202402353"],"URL":"https:\/\/doi.org\/10.1002\/anie.202402353","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2024-5fthz","asserted-by":"object"}]},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,3]]},"assertion":[{"value":"2024-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402353"}}