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However, the asymmetric version of this reaction has remained largely underdeveloped owing to the difficulty in simultaneous control of both regio\u2010 and stereoselectivity. In addition, exploring the wider alkene substrate scope to enable more synthetically valuable applications represents another challenge in this field. In this context, a nickel\u2010catalyzed asymmetric hydrocyanation of internal alkenes involving a chain\u2010walking process is demonstrated. The reaction exhibits excellent regio\u2010 and enantioselectivity, proceeds under mild reaction conditions, and delivers benzylic nitriles in high yields. Even \u03b1,\u03c9\u2010diaryl internal alkenes, which are known to be one of the most challenging substrates of this type, could be successfully converted to the desired products with good regio\u2010 and stereoselectivity by modifying the electronic and steric effects. Theoretical calculations suggest that the <jats:italic>\u03b7<\/jats:italic><jats:sup>3<\/jats:sup>\u2010benzyl coordination mode and the aryl substituent (3,5\u2010(OMe)<jats:sub>2<\/jats:sub>C<jats:sub>6<\/jats:sub>H<jats:sub>3<\/jats:sub>) on the diphosphite ligand are both key factors in regulating regio\u2010 and enantioselectivity.<\/jats:p>","DOI":"10.1002\/anie.202402390","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T03:30:00Z","timestamp":1711337400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nickel\u2010Catalyzed Regio\u2010 and Enantioselective Migratory Hydrocyanation of Internal Alkenes: Expanding the Scope to \u03b1,\u03c9\u2010Diaryl Internal Alkenes"],"prefix":"10.1002","volume":"63","author":[{"given":"Mingdong","family":"Jiao","sequence":"first","affiliation":[{"name":"Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Key Laboratory of Organosilicon Material Technology of Zhejiang Province College of Material Chemistry and Chemical Engineering Hangzhou Normal University  2318 Yuhangtang Road Hangzhou 311121 P. 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