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However, its widespread adoption has been hindered by limited control of the membrane microstructure (pore architecture and free\u2010volume elements), separation threshold, scalability, and operational stability. In this study, 4,4\u2032,4\u2032\u2032,4\u2032\u2032\u2032\u2010methanetetrayltetrakis(benzene\u20101,2\u2010diamine) (MTLB) as prepared as a molecular building block for fabricating thin\u2010film composite membranes (TFCMs) via interfacial polymerization. The relatively large molecular size and rigid molecular structure of MTLB, along with its non\u2010coplanar and distorted conformation, produced thin and defect\u2010free selective layers (~27\u2005nm) with ideal microporosities for antibiotic desalination. These structural advantages yielded an unprecedented high performance with a water permeance of 45.2\u2005L\u2009m\n                    <jats:sup>\u22122<\/jats:sup>\n                    \u2009h\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2009bar\n                    <jats:sup>\u22121<\/jats:sup>\n                    and efficient antibiotic desalination (NaCl\/adriamycin selectivity of 422). We demonstrated the feasibility of the industrial scaling of the membrane into a spiral\u2010wound module (with an effective area of 2.0\u2005m\n                    <jats:sup>2<\/jats:sup>\n                    ). This module exhibited long\u2010term stability and performance that surpassed those of state\u2010of\u2010the\u2010art membranes used for antibiotic desalination. This study provides a scientific reference for the development of high\u2010performance TFCMs for water purification and desalination in the pharmaceutical industry.\n                  <\/jats:p>","DOI":"10.1002\/anie.202402509","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:09:12Z","timestamp":1712574552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Scalable Preparation of Ultraselective and Highly Permeable Fully Aromatic Polyamide Nanofiltration Membranes for Antibiotic Desalination"],"prefix":"10.1002","volume":"63","author":[{"given":"Haohao","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Synthetic and Biological Colloids Ministry of Education School of Chemical and Material Engineering Jiangnan University  214122 Wuxi P.\u2005R. 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