{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:26:14Z","timestamp":1792085174207,"version":"4.4.0"},"reference-count":122,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2004188"],"award-info":[{"award-number":["U2004188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271079"],"award-info":[{"award-number":["22271079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130103"],"award-info":[{"award-number":["82130103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["212300410053"],"award-info":[{"award-number":["212300410053"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021173","name":"Central Plains Scholars and Scientists Studio Fund","doi-asserted-by":"publisher","award":["2018002"],"award-info":[{"award-number":["2018002"]}],"id":[{"id":"10.13039\/501100021173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural redox\u2010regulated channel proteins often utilize disulfide bonds as redox sensors for adaptive regulation of channel conformations in response to diverse physiological environments. In this study, we developed novel synthetic ion channels capable of reversibly switching their ion\u2010transport capabilities by incorporating multiple disulfide bonds into artificial systems. X\u2010ray structural analysis and electrophysiological experiments demonstrated that these disulfide\u2010bridged molecules possess well\u2010defined tubular cavities and can be efficiently inserted into lipid bilayers to form artificial ion channels. More importantly, the disulfide bonds in these molecules serve as redox\u2010tunable switches to regulate the formation and disruption of ion\u2010permeation pathways, thereby achieving a transition in the transmembrane transport process between the ON and OFF states.<\/jats:p>","DOI":"10.1002\/anie.202403667","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T16:04:53Z","timestamp":1708963493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Redox\u2010Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion\u2010Permeation Pathway"],"prefix":"10.1002","volume":"63","author":[{"given":"Linlin","family":"Shi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Jiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Guo","sequence":"additional","affiliation":[{"name":"Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences Macao Polytechnic University  Macao 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhui","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbiao","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-7953","authenticated-orcid":false,"given":"Pengyang","family":"Xin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering Henan Normal University  Xinxiang 453007 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10559"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02770-5"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308603768295168"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0508-4"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2006"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003962"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152710790966650"},{"key":"e_1_2_3_10_1","unstructured":"\u00a0"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06414"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio821"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00240-9"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(03)00055-1"},{"key":"e_1_2_3_15_1","unstructured":"\u00a0"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw7935"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05247-9"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63429"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1540-0"},{"key":"e_1_2_3_20_1","unstructured":"\u00a0"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-05161-1_12"},{"key":"e_1_2_3_22_2","volume-title":"Neuroscience.","author":"Purves D.","year":"2001"},{"key":"e_1_2_3_23_2","volume-title":"Ionic Channels of Excitable Membranes","author":"Hille B.","year":"2001"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3328-3_1"},{"key":"e_1_2_3_25_1","unstructured":"\u00a0"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar00028a009"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar8001393"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400014r"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400025e"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400026x"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400007w"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400129t"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar4000295"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400030e"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400032c"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400044k"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400061d"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar300337f"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00143"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214194"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.99"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00302"},{"key":"e_1_2_3_43_1","unstructured":"\u00a0"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja056888e"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja308342g"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja503376s"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800451"},{"key":"e_1_2_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915287"},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07977"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02815"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00601"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02881"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-00796-x"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c12128"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102838"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01451"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00804"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01315-w"},{"key":"e_1_2_3_59_1","unstructured":"\u00a0"},{"key":"e_1_2_3_60_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60385g"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC08943G"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol8013045"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC01123G"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja962217s"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5NJ00937E"},{"key":"e_1_2_3_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916755"},{"key":"e_1_2_3_67_2","doi-asserted-by":"publisher","DOI":"10.1039\/b809087d"},{"key":"e_1_2_3_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5070312"},{"key":"e_1_2_3_69_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja060515b"},{"key":"e_1_2_3_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200500516"},{"key":"e_1_2_3_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja003141"},{"key":"e_1_2_3_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja972648q"},{"key":"e_1_2_3_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008393"},{"key":"e_1_2_3_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201311249"},{"key":"e_1_2_3_75_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09515"},{"key":"e_1_2_3_76_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c04118"},{"key":"e_1_2_3_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302198"},{"key":"e_1_2_3_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16770-z"},{"key":"e_1_2_3_79_1","unstructured":"\u00a0"},{"key":"e_1_2_3_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202308842"},{"key":"e_1_2_3_81_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC04518J"},{"key":"e_1_2_3_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201101547"},{"key":"e_1_2_3_83_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB00584G"},{"key":"e_1_2_3_84_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB00938E"},{"key":"e_1_2_3_85_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC02872J"},{"key":"e_1_2_3_86_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04417B"},{"key":"e_1_2_3_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006392"},{"key":"e_1_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12892"},{"key":"e_1_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000961"},{"key":"e_1_2_3_90_1","unstructured":"\u00a0"},{"key":"e_1_2_3_91_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr970022c"},{"key":"e_1_2_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)85664-6"},{"key":"e_1_2_3_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199216371"},{"key":"e_1_2_3_94_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501625"},{"key":"e_1_2_3_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200802982"},{"key":"e_1_2_3_96_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc00366b"},{"key":"e_1_2_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813797"},{"key":"e_1_2_3_98_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202217859"},{"key":"e_1_2_3_99_1","unstructured":"\u00a0"},{"key":"e_1_2_3_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol201065u"},{"key":"e_1_2_3_101_2","doi-asserted-by":"publisher","DOI":"10.1039\/b904933a"},{"key":"e_1_2_3_102_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo802139s"},{"key":"e_1_2_3_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.10.039"},{"key":"e_1_2_3_104_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB02464H"},{"key":"e_1_2_3_105_2","doi-asserted-by":"publisher","DOI":"10.1039\/c39840001277"},{"key":"e_1_2_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.09.013"},{"key":"e_1_2_3_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201201729"},{"key":"e_1_2_3_108_1","unstructured":"Deposition numbers 2312369 contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum KarlsruheAccess Structuresservice."},{"key":"e_1_2_3_109_1","unstructured":"\u00a0"},{"key":"e_1_2_3_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780199634750.001.0001"},{"key":"e_1_2_3_111_2","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15099E"},{"key":"e_1_2_3_112_1","first-page":"473","volume-title":"Supramolecular Chemistry: From Molecules to Nanomaterials, Vol. 8","author":"Matile S.","year":"2012"},{"key":"e_1_2_3_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo961267c"},{"key":"e_1_2_3_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06000"},{"key":"e_1_2_3_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(89)80004-7"},{"key":"e_1_2_3_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.397380"},{"key":"e_1_2_3_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18593"},{"key":"e_1_2_3_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000880"},{"key":"e_1_2_3_119_1","unstructured":"\u00a0"},{"key":"e_1_2_3_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"e_1_2_3_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21367"},{"key":"e_1_2_3_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202403667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T20:30:51Z","timestamp":1715027451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202403667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":122,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2024,5,13]]}},"alternative-id":["10.1002\/anie.202403667"],"URL":"https:\/\/doi.org\/10.1002\/anie.202403667","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"2024-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202403667"}}