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In order to interface fluorocarbon oils with biological systems, non\u2010ionic fluorosurfactants are necessary. However, there is a paucity of non\u2010ionic fluorosurfactants with low interfacial tension (IFT) to stabilize fluorocarbon phases in aqueous environments (such as oil\u2010in\u2010water emulsions). We developed non\u2010ionic fluorosurfactants composed of a polyethylene glycol (PEG) segment covalently bonded to a flexible perfluoropolyether (PFPE) segment that confer low IFTs between a fluorocarbon oil (HFE\u20107700) and water. The synthesis of a panel of surfactants spanning a molecular weight range of 0.64\u201366\u2005kDa with various hydrophilic\u2010lipophilic balances allowed for identification of minimal IFTs, ranging from 1.4 to 17.8 mN m\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The majority of these custom fluorosurfactants display poor solubility in water, allowing their co\u2010introduction with fluorocarbon oils and minimal leaching. We applied the PEG\n                    <jats:sub>5<\/jats:sub>\n                    PFPE\n                    <jats:sub>1<\/jats:sub>\n                    surfactant for mechanical force measurements in zebrafish, enabling exceptional sensitivity.\n                  <\/jats:p>","DOI":"10.1002\/anie.202404956","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T02:55:24Z","timestamp":1727492124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non\u2010Ionic Fluorosurfactants for Droplet\u2010Based\n                    <i>in vivo<\/i>\n                    Applications"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-6325","authenticated-orcid":false,"given":"Heidi L.","family":"van de Wouw","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of California, Los Angeles  607 Charles E. 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