{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:11:04Z","timestamp":1790223064768,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Given the tremendous success of (p\u2010cymene)Ru<jats:sup>II<\/jats:sup>\u2010catalyzed C\u2212H activation over the past 20\u2005years, the community has long been aware that the development of chiral \u03b7<jats:sup>6<\/jats:sup>\u2010benzene (Ben) ligands should be a potent strategy for achieving the attractive but incredibly underdeveloped ruthenium(II)\u2010catalyzed asymmetric C\u2212H activation. However, it has rarely been achieved due to the severe difficulty in developing proper chiral Ben ligands. In particular, designing chiral Ben ligands by connecting a benzene fragment to a chiral framework including benzene rings remained an unsolved challenge until this effort. Here we present a novel class of axially chiral Ben ligands derived from readily available (<jats:italic>S<\/jats:italic>)\u20105,5\u2032,6,6\u2032,7,7\u2032,8,8\u2032\u2010octahydro\u20101,1\u2032\u2010bi\u20102\u2010naphthol ((<jats:italic>S<\/jats:italic>)\u2010H<jats:sub>8<\/jats:sub>\u2010BINOL) in 4\u20138 steps. Notably, when coordinated with ruthenium, such chiral Ben ligand containing three benzene rings only forms one of the three possible isomeric BenRu<jats:sup>II<\/jats:sup> complexes. The related chiral BenRu<jats:sup>II<\/jats:sup> catalysts could effectively catalyze the asymmetric C\u2212H activation of N\u2010sulfonyl ketimines with alkynes, affording a range of chiral spirocyclic sultams in up to 99\u2009% yield with up to &gt;99\u2009% ee. These catalysts are expected to find broad applications in future.<\/jats:p>","DOI":"10.1002\/anie.202405782","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T22:14:40Z","timestamp":1714342480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["H<sub>8<\/sub>\u2010BINOL\u2010Derived Chiral \u03b7<sup>6<\/sup>\u2010Benzene Ligands: New Opportunities for the Ruthenium\u2010Catalyzed Asymmetric C\u2212H Activation"],"prefix":"10.1002","volume":"63","author":[{"given":"Junxuan","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University  Guangzhou 510006 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University  Guangzhou 510006 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicong","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemistry, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University  Guangzhou 510006 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University  Guangzhou 510006 P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4035-2786","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, and Guangdong Key Laboratory of Chiral Molecule and Drug Discovery Sun Yat-Sen University  Guangzhou 510006 P.\u2005R. 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