{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:07:15Z","timestamp":1790788035356,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/X015262\/1"],"award-info":[{"award-number":["EP\/X015262\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alkyl chlorides are a class of versatile building blocks widely used to generate C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2010rich scaffolds through transformation such as nucleophilic substitution, radical addition reactions and metal\u2010catalyzed cross\u2010coupling processes. Despite their utility in the synthesis of high\u2010value functional molecules, distinct methods for the preparation of alkyl chlorides are underrepresented. Here, we report a visible\u2010light\u2010mediated dual catalysis strategy for the modular synthesis of highly functionalized and structurally diverse arylated chloroalkanes via the coupling of diaryliodonium salts, alkenes and potassium chloride. A distinctive aspect of this transformation is a ligand\u2010design\u2010driven approach for the development of a copper(II)\u2010based atom\u2010transfer catalyst that enables the aryl\u2010chlorination of electron\u2010poor alkenes, complementing its iron(III)\u2010based counterpart that accommodates non\u2010activated aliphatic alkenes and styrene derivatives. The complementarity of the two dual catalytic systems allows the efficient aryl\u2010chlorination of alkenes bearing different stereo\u2010electronic properties and a broad range of functional groups, maximizing the structural diversity of the 1\u2010aryl, 2\u2010chloroalkane products.\n                  <\/jats:p>","DOI":"10.1002\/anie.202405939","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T06:50:10Z","timestamp":1721717410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Modular Dual\u2010Catalytic Aryl\u2010Chlorination of Alkenes"],"prefix":"10.1002","volume":"63","author":[{"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Bunescu","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Drazen","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Rolph","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Michalland","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"},{"name":"Innovation Centre in Digital Molecular Technologies Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"},{"name":"Compound Synthesis &amp; Management, Discovery Sciences, Biopharmaceuticals R&amp;D The Discovery Centre, AstraZeneca Biomedical Campus  1 Francis Crick Avenue Cambridge United Kingdom CB2 0AA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-608X","authenticated-orcid":false,"given":"Matthew J.","family":"Gaunt","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"},{"name":"Innovation Centre in Digital Molecular Technologies Yusuf Hamied Department of Chemistry University of Cambridge  Lensfield Road Cambridge United Kingdom CB2 1EW"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00316F"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00110E"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00022a008"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803611"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja501815p"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12749"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8611"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja066380r"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1591872"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1sc00175b"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06466"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01705"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02095"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01135a026"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100145"},{"key":"e_1_2_3_18_1","unstructured":"\u00a0"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016548"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09388"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b12308"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b00582"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2000"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-023-00914-7"},{"key":"e_1_2_3_25_1","unstructured":"\u00a0"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18751790305"},{"key":"e_1_2_3_27_2","first-page":"2254","volume":"19","author":"Mokijewski","year":"1895","journal-title":"Chem.-Ztg. 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