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Therefore, developing rapid and noninvasive strategies direct responsive to renal tubular acidic microenvironment rather than delayed biomarkers are essential for timely renoprotective interventions. Herein, we develop pH\u2010responsive luminescent gold nanoparticles (p\u2010AuNPs) in the second near\u2010infrared emission co\u2010coated with 2,3\u2010dimethylaleic anhydride conjugated \u03b2\u2010mercaptoethylamine and cationic 2\u2010diethylaminoethanethiol hydrochloride, which showed sensitive pH\u2010induced charge reversal and intrarenal self\u2010assembly for highly sensitive and long\u2010time (~24\u2005h) imaging of different stages of MAKI. By integrating advantages of pH\u2010induced intrarenal self\u2010assembly and enhanced interactions between pH\u2010triggered positively charged p\u2010AuNPs and renal tubular cells, the early\u2010 and late\u2010stage MAKI could be differentiated rapidly within 10\u2005min post\u2010injection (p.i.) with contrast index (CI) of 3.5 and 4.3, respectively. The corresponding maximum CI could reach 5.1 and 9.2 at 12\u2005h p.i., respectively. Furthermore, p\u2010AuNPs were demonstrated to effectively real\u2010time monitor progressive recovery of kidney injury in MAKI mice after therapy, and also exhibit outstanding capabilities for drug screening. This pH\u2010responsive strategy showed great promise for feedback on kidney dysfunction progression, opening new possibilities for early\u2010stage diagnosis of pH\u2010related diseases.<\/jats:p>","DOI":"10.1002\/anie.202406016","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T05:50:38Z","timestamp":1714801838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Intrarenal pH\u2010Responsive Self\u2010Assembly of Luminescent Gold Nanoparticles for Diagnosis of Early Kidney Injury"],"prefix":"10.1002","volume":"63","author":[{"given":"Zhipeng","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pulp and Paper Engineering, School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510640 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pulp and Paper Engineering, School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-131X","authenticated-orcid":false,"given":"Jinbin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pulp and Paper Engineering, School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.044"},{"key":"e_1_2_8_2_1","unstructured":"\u00a0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.33"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.186"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2022.07.005"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0493-3"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2022.02.011"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71055-2"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/jtim-2016-0036"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.06.005"},{"key":"e_1_2_8_12_1","unstructured":"\u00a0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.068"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.122"},{"key":"e_1_2_8_15_1","unstructured":"\u00a0"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0378-4"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511148"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1624"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00284-z"},{"key":"e_1_2_8_20_1","unstructured":"\u00a0"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019070677"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103071"},{"key":"e_1_2_8_24_1","unstructured":"\u00a0"},{"key":"e_1_2_8_25_2","volume":"62","author":"Nie W.","year":"2023","journal-title":"Angew. 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