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However, existing molecular diagnostic methods normally suffer from high cost, cumbersome procedures, dependence on specialized equipment and the requirement of in\u2010depth expertise in data analysis, failing to analyze multiple cancer\u2010associated nucleic acid markers and provide immediate results in a point\u2010of\u2010care manner. Herein, we demonstrate a transistor\u2010based DNA molecular computing (TDMC) platform that enables simultaneous detection and logical analysis of multiple microRNA (miRNA) markers on a single transistor. TDMC can perform not only basic logical operations such as \u201cAND\u201d and \u201cOR\u201d, but also complex cascading computing, opening up new dimensions for multi\u2010index logical analysis. Owing to the high efficiency, sensing and computations of multi\u2010analytes can be operated on a transistor at a concentration as low as 2\u00d710\n                    <jats:sup>\u221216<\/jats:sup>\n                    M, reaching the lowest concentration for DNA molecular computing. Thus, TDMC achieves an accuracy of 98.4\u2009% in the diagnosis of hepatocellular carcinoma from 62 serum samples. As a convenient and accurate platform, TDMC holds promise for applications in \u201cone\u2010stop\u201d personalized medicine.\n                  <\/jats:p>","DOI":"10.1002\/anie.202407039","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T23:55:50Z","timestamp":1721606150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["DNA Logical Computing on a Transistor for Cancer Molecular Diagnosis"],"prefix":"10.1002","volume":"63","author":[{"given":"Derong","family":"Kong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science  Shanghai 200433 P. R. China"},{"name":"Laboratory of Molecular Materials and Devices Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science  Shanghai 200433 P. R. China"},{"name":"Laboratory of Molecular Materials and Devices Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinye","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science  Shanghai 200433 P. R. China"},{"name":"Laboratory of Molecular Materials and Devices Fudan University  Shanghai 200433 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetong","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science  Shanghai 200433 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-9897","authenticated-orcid":false,"given":"Dacheng","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science  Shanghai 200433 P. R. China"},{"name":"Laboratory of Molecular Materials and Devices Fudan University  Shanghai 200433 P. R. 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