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However, their user as switchable motifs in the construction of multi\u2010component supramolecular structures remains poorly explored. Here, we report a molecular cage\u2005\n                    <jats:bold>1<\/jats:bold>\n                    , which consists of a bent anthracene dimer\n                    <jats:bold>3<\/jats:bold>\n                    paired with 1,3,5\u2010tris(aminomethyl)\u20102,4,6\u2010triethylbenzene\n                    <jats:bold>2<\/jats:bold>\n                    . As the result of the pH\u2010induced\n                    <jats:italic>ababab<\/jats:italic>\n                    \u2194\n                    <jats:italic>bababa<\/jats:italic>\n                    isomerization of the constituent\u2010functionalized benzene units derived from\n                    <jats:bold>2<\/jats:bold>\n                    , this cage can reversibly convert between an open state and a closed form, both in solution and in the solid state. Cage\u2005\n                    <jats:bold>1<\/jats:bold>\n                    was used to create stimuli\u2010responsive hierarchical superstructures, namely Russian doll\u2010like complexes with [K\u228218\u2010crown\u20106\u2282\n                    <jats:bold>1<\/jats:bold>\n                    ]\n                    <jats:sup>+<\/jats:sup>\n                    and [K\u2282cryptand\u2010222\u2282\n                    <jats:bold>1<\/jats:bold>\n                    ]\n                    <jats:sup>+<\/jats:sup>\n                    . The reversible assembly and disassembly of these superstructures could be induced by switching cage\u2005\n                    <jats:bold>1<\/jats:bold>\n                    from its open to closed form. The present study thus provides an unusual example where pH\u2010triggered conformation motion within a cage\u2010like scaffold is used to control the formation and disassociation of hierarchical ensembles.\n                  <\/jats:p>","DOI":"10.1002\/anie.202407805","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T13:03:41Z","timestamp":1718283821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["1,3,5\u20132,4,6\u2010Functionalized Benzene Molecular Cage: An Environmentally Responsive Scaffold that Supports Hierarchical Superstructures"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1460-3123","authenticated-orcid":false,"given":"Xin\u2010Yu","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Chemistry Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-3514","authenticated-orcid":false,"given":"Hang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Hong Kong  Hong Kong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-8362","authenticated-orcid":false,"given":"Xiaojiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Chemistry Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7683-5811","authenticated-orcid":false,"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Southern University of Science and Technology  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-1325","authenticated-orcid":false,"given":"Jonathan L.","family":"Sessler","sequence":"additional","affiliation":[{"name":"College of Chemistry The University of Texas at Austin  Austin Texas 78712-1224 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-7657","authenticated-orcid":false,"given":"Han\u2010Yuan","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500104k"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00308"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00109K"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00779G"},{"key":"e_1_2_7_6_1","unstructured":"\u00a0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01387-8"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c10084"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201607693"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201703357"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10526"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b01241"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06190"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015597"},{"key":"e_1_2_7_15_1","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193928"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja035621h"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC09911A"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c01204"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5101307"},{"key":"e_1_2_7_22_1","unstructured":"\u00a0"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20020517)8:10<2218::AID-CHEM2218>3.0.CO;2-H"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00410a015"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00248-4"},{"key":"e_1_2_7_26_1","unstructured":"For selected reviews see:"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.001"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.8.1"},{"key":"e_1_2_7_29_1","unstructured":"For selected molecular cages see:"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0155-z"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199723401"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00120"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC00927G"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602412"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201814243"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00468"},{"key":"e_1_2_7_37_1","unstructured":"For selected tripodal receptors see:"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja045813s"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC05737J"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199708621"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00067a094"},{"key":"e_1_2_7_42_1","unstructured":"Scifinder substructure searches were conducted for 1 3 5-trialkylbenzene bearing 2 4 6 substituents of the following type CH2N\u2212 CH2O\u2212 CH2S\u2212 and CH2Ph\u2212."},{"key":"e_1_2_7_43_1","unstructured":"\u00a0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja2037029"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00301"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112267"},{"key":"e_1_2_7_47_1","volume-title":"MOPAC, Stewart Computational Chemistry","author":"Stewart J. 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These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/anie.202407805","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202407805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:29:00Z","timestamp":1741724940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202407805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":72,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2024,9,2]]}},"alternative-id":["10.1002\/anie.202407805"],"URL":"https:\/\/doi.org\/10.1002\/anie.202407805","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"2024-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202407805"}}