{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:54:31Z","timestamp":1791539671435,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22001204"],"award-info":[{"award-number":["22001204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JQ-124"],"award-info":[{"award-number":["2022JQ-124"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012022029"],"award-info":[{"award-number":["xzy012022029"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dearomative cycloadditions are powerful synthetic transformations utilizing aromatic compounds for cycloaddition reactions. They have been extensively applied to the synthesis of biologically relevant compounds not only because of the complexity generated from simplicity but also the atom\u2010 and step\u2010economy. For the most studied yet challenging benzene ring systems, <jats:italic>ortho<\/jats:italic>\u2010 and <jats:italic>para<\/jats:italic>\u2010cycloadditions have been realized both photochemically and thermally, while the <jats:italic>meta<\/jats:italic>\u2010cycloadditions are still limited to the photochemical processes tracing back to the 1960s. Herein, we for the first time realized the thermal cycloadditions of benzene rings with alkenes in a <jats:italic>meta<\/jats:italic> fashion via Wheland intermediates. A broad spectrum of readily available C(sp<jats:sup>2<\/jats:sup>)\u2010rich aniline\u2010tethered enynes were transformed into C(sp<jats:sup>3<\/jats:sup>)\u2010rich 3D complex polycyclic architectures simply by stirring in TFA. Moreover, the reaction could be performed in gram\u2010scales and the products could be diversely elaborated.<\/jats:p>","DOI":"10.1002\/anie.202407841","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T05:43:50Z","timestamp":1717566230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dearomative Intramolecular <i>meta<\/i>\u2010Thermocycloadditions of Benzene Rings via Wheland Intermediates"],"prefix":"10.1002","volume":"63","author":[{"given":"Shupeng","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University (XJTU)  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University (XJTU)  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University (XJTU)  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-3616","authenticated-orcid":false,"given":"Youliang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry Xi'an Jiaotong University (XJTU)  Xi'an 710049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00018a002"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00005"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2021.132087"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00412"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac199062081597"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/B614011B"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00532J"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00389K"},{"key":"e_1_2_3_11_1","unstructured":"\u00a0"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00961a052"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/c19660000512"},{"key":"e_1_2_3_14_1","unstructured":"\u00a0"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198206201"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01188-z"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)89880-4"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704155"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02314"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01106"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00208a028"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00330a065"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016899"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2594"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2020.577"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)96474-3"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201005779"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5044825"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02556"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC04421A"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12894"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310066"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07726"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC04005K"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg0720"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.10.016"},{"key":"e_1_2_3_37_1","unstructured":"\u00a0"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)95956-8"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00326a014"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00386a017"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)91256-6"},{"key":"e_1_2_3_42_1","unstructured":"\u00a0"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)91721-6"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1039\/p19890001867"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)61972-X"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)61929-9"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19861050602"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00164"},{"key":"e_1_2_3_49_1","unstructured":"\u00a0"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200400313"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.1992"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo000861q"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200460292"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02984"},{"key":"e_1_2_3_55_1","unstructured":"\u00a0"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC04010E"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c01234"},{"key":"e_1_2_3_58_1","unstructured":"Deposition numbers 2314171 (for10) and 2329115 (for51) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum KarlsruheAccess Structuresservice."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202407841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:46:59Z","timestamp":1724046419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202407841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":58,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2024,8,26]]}},"alternative-id":["10.1002\/anie.202407841"],"URL":"https:\/\/doi.org\/10.1002\/anie.202407841","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"2024-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202407841"}}