{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:50:09Z","timestamp":1790639409189,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0704000, 2020YFA0908800"],"award-info":[{"award-number":["2018YFA0704000, 2020YFA0908800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor\u2010specific activatable long\u2010wavelength (LW) photosensitizers (PSs) show promise in overcoming the limitations of traditional photodynamic therapy (PDT), such as systemic phototoxicity and shallow tissue penetration. However, their insufficient LW light absorption and low singlet oxygen quantum yield (<jats:italic>\u03a6<\/jats:italic> <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) usually require high laser power density to produce thermal energy and synergistically enhance PDT. The strong photothermal radiation causing acute pain significantly reduces patient compliance and hinders the broader clinical application of LW PDT. Through the exciton dynamics dissection strategy, we have developed a series of pH\u2010activatable cyanine\u2010based LW PSs (LET\u2010R, R = H, Cl, Br, I), among which the activated LET\u2010I exhibits strong light absorption at 808\u2005nm and a remarkable 3.2\u2010fold enhancement in <jats:italic>\u03a6<\/jats:italic> <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> compared to indocyanine green. Transient spectroscopic analysis and theoretical calculations confirmed its significantly promoted intersystem crossing and simultaneously enhanced LW fluorescence emission characteristics. These features enable the activatable fluorescence and photoacoustic dual\u2010modal imaging\u2010escorted complete photodynamic eradication of tumors by the folic acid (FA)\u2010modified LET\u2010I probe (LET\u2010I\u2010FA), under the ultralow 808\u2005nm laser power density (0.2\u2005W\u2009cm<jats:sup>\u22122<\/jats:sup>) for irradiation, without the need for photothermal energy synergy. This research presents a novel strategy of dissecting exciton dynamics to screen activatable LW PSs for traceable PDT.<\/jats:p>","DOI":"10.1002\/anie.202408064","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T02:30:44Z","timestamp":1717986644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Dissecting Exciton Dynamics in pH\u2010Activatable Long\u2010Wavelength Photosensitizers for Traceable Photodynamic Therapy"],"prefix":"10.1002","author":[{"given":"Yurong","family":"Liu","sequence":"first","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Sino-German Intelligent Manufacturing Shenzhen Institute of Technology  Shenzhen 518116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lei","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangle","family":"Feng","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering, Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-2098","authenticated-orcid":false,"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Medical School Shenzhen University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/s41557-023-01242-w","volume":"15","author":"Deng Z.","year":"2023","journal-title":"Nat. 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