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Therefore, polysulfide construction is in great demand. The controllable sequential installation of groups on both ends of a S\u2212S motif faces an enormous challenge owing to the reversible nature of the covalent S\u2212S bond. A library was established with two divergent mask groups for bilateral unsymmetrical disulfurating reagents (R\n                    <jats:sup>1<\/jats:sup>\n                    O\u2212SS\u2212SO\n                    <jats:sub>2<\/jats:sub>\n                    R\n                    <jats:sup>2<\/jats:sup>\n                    ). Sequential coupling with preferential activation of the S\u2212SO\n                    <jats:sub>2<\/jats:sub>\n                    bond (37.6\u2005kcal\/mol) and controllable activation of the S\u2212O bond (54.8\u2005kcal\/mol) in the presence of the S\u2212S bond (62.0\u2005kcal\/mol) enabled successive reactions at each end of the S\u2212S motif to afford unsymmetrical disulfides and trisulfides, even for the cross\u2010linkage of natural products, pharmaceuticals, peptides, and a protein (bovine serum albumin).\n                  <\/jats:p>","DOI":"10.1002\/anie.202408158","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T22:24:20Z","timestamp":1719354260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Bilateral Unsymmetrical Disulfurating Reagent Design for Polysulfide Construction"],"prefix":"10.1002","volume":"63","author":[{"given":"Qing","family":"Yu","sequence":"first","affiliation":[{"name":"Hainan Institute of East China Normal University State Key Laboratory of Petroleum Molecular &amp; Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Shanghai 200062 P.R. 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