{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:47:19Z","timestamp":1790858839427,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","award":["Liebig Fellowship"],"award-info":[{"award-number":["Liebig Fellowship"]}],"id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["491117731"],"award-info":[{"award-number":["491117731"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["527736106"],"award-info":[{"award-number":["527736106"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isomerisation reactions provide streamlined routes to organic compounds which are otherwise hard to directly synthesise. The most common forms are positional, geometrical or stereochemical isomerisations which involve the relocation of a double bond or a change in relative location of groups in space. In contrast, far fewer examples of structural (or constitutional) isomerisation exist where the connectivity between atoms is altered. The development of platforms capable of such rearrangement poses a unique set of challenges because chemical bonds must be selectively cleaved, and new ones formed without overall addition or removal of atoms. Here, we show that a dual catalytic system can enable the structural isomerisation of readily available allylic alcohols into more challenging\u2010to\u2010synthesise \u03b1\u2010arylated ketones via a H\u2010atom transfer initiated semi\u2010pinacol rearrangement. Key to our strategy is the combination of a cobalt catalyst and photocatalyst under reductive, protic conditions which allows intermediates to propagate catalytic turnover. By providing an unusual disconnection to structural motifs which are difficult to access through direct arylation, we anticipate inspiring other advanced catalytic isomerisation strategies that will further retrosynthetic logic for complex molecule synthesis.<\/jats:p>","DOI":"10.1002\/anie.202409388","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T02:32:30Z","timestamp":1720492350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dual\u2010Catalytic Structural Isomerisation as a Route to \u03b1\u2010Arylated Ketones"],"prefix":"10.1002","volume":"63","author":[{"given":"Danijela","family":"Lunic","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Vystavkin","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"},{"name":"Institute of Organic Chemistry TU Braunschweig  Hagenring 30 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Qin","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University  Landoltweg 1 52074 Aachen Germany"},{"name":"Institute of Organic Chemistry TU Braunschweig  Hagenring 30 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-5674","authenticated-orcid":false,"given":"Christopher J.","family":"Teskey","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry TU Braunschweig  Hagenring 30 38106 Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906124"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1610"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11681"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12043"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07136"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7235"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00324"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add6852"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1937-1"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0755-1"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay2204"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06407-8"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202105285"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200903424"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0201106"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9727880"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja972593s"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1246\/bcsj.71.2239"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2082087"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0521201"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja200009c"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303305"},{"key":"e_1_2_3_23_1","first-page":"24958","volume":"145","author":"Wang J.","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05109"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310639"},{"key":"e_1_2_3_26_1","author":"Mayerhofer V. J.","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20872-z"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08278"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04595-3"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00334"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04112B"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304882"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA20007A"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12075"},{"key":"e_1_2_3_35_1","author":"Deng M.","year":"2023","journal-title":"Org. Lett."},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c00527"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10133"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10989"},{"key":"e_1_2_3_39_1","author":"Lindner H.","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202100446"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202208028"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30395-4"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-021-1188-x"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201603517"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03692"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-022-00108-2"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02436"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00749"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0545463"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05194B"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154558"},{"key":"e_1_2_3_52_1","unstructured":"A creative desymmetrisation approach using oxidative MHAT appeared as a pre-print during the revision of this manuscript: P.\u2005G. Kalomenopoulos B. Emayavaramban C.\u2005P. Johnston2024 DOI10.26434\/chemrxiv-2024-59kcj."},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00381"},{"key":"e_1_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00622"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00582"},{"key":"e_1_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200702146"},{"key":"e_1_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c13236"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202409388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T08:31:53Z","timestamp":1730363513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202409388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,24]]},"references-count":57,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2024,10,24]]}},"alternative-id":["10.1002\/anie.202409388"],"URL":"https:\/\/doi.org\/10.1002\/anie.202409388","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,24]]},"assertion":[{"value":"2024-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202409388"}}