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The ligand is designed with \u201cside\u2010arm\u2010wall\u201d substituents that allow vicinal di\u2010 or multi\u2010substituted benzene derivatives to approach metal center and effectively block other reactive sites by non\u2010covalent interactions with substrates. The effectiveness of this strategy is demonstrated by the successful selective distal C\u2212H activation of various alkaloids and its broad compatibility with functional groups.<\/jats:p>","DOI":"10.1002\/anie.202411158","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T15:08:50Z","timestamp":1721056130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spirobipyridine Ligand Enabled Iridium\u2010Catalyzed Site\u2010Selective C\u2212H Activation via Non\u2010Covalent Interactions"],"prefix":"10.1002","author":[{"given":"Kun","family":"Dong","sequence":"first","affiliation":[{"name":"School of Chemistry Dalian University of Technology  Dalian Liaoning 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-0886","authenticated-orcid":false,"given":"Luqing","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chemistry Dalian University of Technology  Dalian Liaoning 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","unstructured":"G. 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