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Biological ion channels occasionally demonstrate multiple conductance states (known as subconductance), remaining a challenging property to achieve in artificial channel molecules. We report a funnel\u2010shaped single\u2010molecule channel constructed by an electron\u2010deficient macrocycle and two electron\u2010deficient aromatic imide arms. Planar lipid bilayer measurements reveal distinct current recordings, including a closed state, two conducting states, and spontaneous transitions between the three states, resembling the events seen in biological ion channels. The transitions result from conformational changes induced by chloride transport in the channel molecule. Both opening states show a non\u2010linear and rectifying I\u2013V relationship, indicating voltage\u2010dependent transport due to the asymmetrical channel structure. This work could enhance our understanding of ion permeation and channel opening mechanism.<\/jats:p>","DOI":"10.1002\/anie.202411702","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T02:28:44Z","timestamp":1720492124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous Transition between Multiple Conductance States and Rectifying Behaviors in an Artificial Single\u2010Molecule Funnel"],"prefix":"10.1002","volume":"63","author":[{"given":"Jia\u2010Fen","family":"Lin","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences  Beijing 100190 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 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