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Despite several recent advances, the development of highly reactive tetrazines enabling quantitative elimination from\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010cyclooctene linkers remains challenging. In this study, we present the synthesis and application of sulfo\u2010tetrazines, a class of derivatives featuring phenolic hydroxyl groups with increased acidity constants (p\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    ). This unique property leads to accelerated elimination and complete release of the caged molecules within minutes. Moreover, the inclusion of sulfonate groups provides a valuable synthetic handle, enabling further derivatization into sulfonamides, modified with diverse substituents. 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