{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:38:55Z","timestamp":1792226335211,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21925802"],"award-info":[{"award-number":["21925802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22078046"],"award-info":[{"award-number":["22078046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22338005"],"award-info":[{"award-number":["22338005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278061"],"award-info":[{"award-number":["22278061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT22LAB601"],"award-info":[{"award-number":["DUT22LAB601"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Near\u2010infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen (<jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>) generation ability, indicated by low <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S (<jats:bold>Scy7<\/jats:bold>) and Se (<jats:bold>Secy7<\/jats:bold>) atom. We observe that <jats:bold>Secy7<\/jats:bold> exhibits a redshift in the main absorption to ~840\u2005nm and an ultra\u2010efficient <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> generation capacity. The emergence of a strong intramolecular charge transfer effect between the Se atom and polymethine chain considerably narrows the energy gap (0.51\u2005eV), and the heavy atom effect of Se strengthens spin\u2013orbit coupling (1.44\u2005cm<jats:sup>\u22121<\/jats:sup>), both of which greatly improved the high triplet state yield (61\u2009%), a state that determines the energy transfer to O<jats:sub>2<\/jats:sub>. Therefore, <jats:bold>Secy7<\/jats:bold> demonstrated excellent <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> generation capacity, which is ~24.5\u2010fold that of indocyanine green, ~8.2\u2010fold that of IR780, and ~1.3\u2010fold that of methylene blue under low\u2010power\u2010density 850\u2005nm irradiation (5\u2005mW\u2009cm<jats:sup>\u22122<\/jats:sup>). <jats:bold>Secy7<\/jats:bold> exhibits considerable phototoxicity toward cancer cells buried under 12\u2005mm of tissue. Nanoparticles formed by encapsulating <jats:bold>Secy7<\/jats:bold> within amphiphilic polymers and lecithin, demonstrated promising antitumor and anti\u2010pulmonary metastatic effects, exhibiting remarkable potential for advancing PDT in deep tissues.<\/jats:p>","DOI":"10.1002\/anie.202411802","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:40:54Z","timestamp":1722411654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Near\u2013Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy"],"prefix":"10.1002","volume":"63","author":[{"given":"Wenkai","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study Hong Kong University of Science and Technology  Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Dalian University of Technology  Panjin 124221 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Gu","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Dalian University of Technology  Ningbo 315016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfang","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Dalian University of Technology  Panjin 124221 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"},{"name":"Liaoning Binhai Laboratory  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-5350","authenticated-orcid":false,"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo 315016 China"},{"name":"Liaoning Binhai Laboratory  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangli","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"},{"name":"Ningbo Institute of Dalian University of Technology  Ningbo 315016 China"},{"name":"Liaoning Binhai Laboratory  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials Dalian University of Technology  Dalian 116024 China"},{"name":"Liaoning Binhai Laboratory  Dalian 116023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01135"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110832"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b09220"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101392"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318783"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305187"},{"key":"e_1_2_7_8_2","author":"Wei K.","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301770"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109631"},{"key":"e_1_2_7_11_1","unstructured":"\u00a0"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11800"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00734"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400249"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/smo.20230014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01299"},{"key":"e_1_2_7_17_1","unstructured":"\u00a0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901607"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07022"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01422-2"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00506"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00616G"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202109929"},{"key":"e_1_2_7_24_1","unstructured":"\u00a0"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04981"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08434-4"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.11.007"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00102K"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316425"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3735"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218768"},{"key":"e_1_2_7_32_1","unstructured":"\u00a0"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.12.009"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202885"},{"key":"e_1_2_7_35_1","unstructured":"\u00a0"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh1037"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01367-y"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06275"},{"key":"e_1_2_7_39_1","unstructured":"\u00a0"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00001"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b02721"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215367"},{"key":"e_1_2_7_43_1","unstructured":"\u00a0"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.526"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100945"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303186"},{"key":"e_1_2_7_47_1","unstructured":"\u00a0"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04342"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30721-w"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC04840A"},{"key":"e_1_2_7_51_1","unstructured":"\u00a0"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201301771"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-021-1179-7"},{"key":"e_1_2_7_55_1","unstructured":"\u00a0"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119671"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC04034J"},{"key":"e_1_2_7_58_1","unstructured":"\u00a0"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/00268977000100171"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202100398"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27914-0"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2022.04.043"},{"key":"e_1_2_7_63_1","unstructured":"\u00a0"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08602"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46768-w"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36679-7"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05390"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990402t"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300340"},{"key":"e_1_2_7_70_1","unstructured":"\u00a0"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12874"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800295"},{"key":"e_1_2_7_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103334"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202411802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T08:03:21Z","timestamp":1732781001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202411802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,17]]},"references-count":73,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2024,11,18]]}},"alternative-id":["10.1002\/anie.202411802"],"URL":"https:\/\/doi.org\/10.1002\/anie.202411802","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,17]]},"assertion":[{"value":"2024-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202411802"}}