{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:38Z","timestamp":1790776418519,"version":"4.1.0"},"reference-count":139,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0002"],"award-info":[{"award-number":["ANR-10-IDEX-0002"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-23-CE07-0050-01"],"award-info":[{"award-number":["ANR-23-CE07-0050-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["CSC-IGS ANR-17-EURE-0016"],"award-info":[{"award-number":["CSC-IGS ANR-17-EURE-0016"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    1,2\u2010Diamination of alkenes represents an attractive way to generate differentiated vicinal diamines, which are prevalent motifs in biologically active compounds and catalysts. However, existing methods are usually limited in scope and produce diamines where one or both nitrogens are protected, adding synthetic steps for deprotection and further N\u2010functionalization to reach a desired target. Furthermore, the range of amino groups that can be introduced at the internal position is fairly limited. Here we describe a 1,2\u2010diamination of styrenes that directly installs a free amino group at the terminal position and a wide variety of unprotected nitrogen nucleophiles (primary or secondary alkyl or aromatic amines, sulfoximines,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocycles, and ammonia surrogate) at the internal position. Two complementary sets of conditions encompass electronically activated and deactivated styrenes with diverse substitution patterns and functional groups. Moreover, this strategy can be extended to the 1,2\u2010aminothiolation of styrenes.\n                  <\/jats:p>","DOI":"10.1002\/anie.202411992","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T05:16:01Z","timestamp":1721193361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Iron(II)\u2010Catalyzed 1,2\u2010Diamination of Styrenes Installing a Terminal NH\n                    <sub>2<\/sub>\n                    Group Alongside Unprotected Amines"],"prefix":"10.1002","volume":"63","author":[{"given":"Valentyn","family":"Pozhydaiev","sequence":"first","affiliation":[{"name":"Institut de Science et d'Ing\u00e9nierie Supramol\u00e9culaires (ISIS) CNRS UMR 7006 Universit\u00e9 de Strasbourg  8 All\u00e9e Gaspard Monge 67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Paparesta","sequence":"additional","affiliation":[{"name":"Institut de Science et d'Ing\u00e9nierie Supramol\u00e9culaires (ISIS) CNRS UMR 7006 Universit\u00e9 de Strasbourg  8 All\u00e9e Gaspard Monge 67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7851-6133","authenticated-orcid":false,"given":"Joseph","family":"Moran","sequence":"additional","affiliation":[{"name":"Institut de Science et d'Ing\u00e9nierie Supramol\u00e9culaires (ISIS) CNRS UMR 7006 Universit\u00e9 de Strasbourg  8 All\u00e9e Gaspard Monge 67000 Strasbourg France"},{"name":"Department of Chemistry and Biomolecular Sciences University of Ottawa  Ottawa Ontario K1N 6N5 Canada"},{"name":"Institut Universitaire de France (IUF)  75005 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-7609","authenticated-orcid":false,"given":"David","family":"Leb\u0153uf","sequence":"additional","affiliation":[{"name":"Institut de Science et d'Ing\u00e9nierie Supramol\u00e9culaires (ISIS) CNRS UMR 7006 Universit\u00e9 de Strasbourg  8 All\u00e9e Gaspard Monge 67000 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"For selected reviews see:"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19981016)37:19<2580::AID-ANIE2580>3.0.CO;2-L"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2006.00347.x"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/c0sc00107d"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00200A"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00074"},{"key":"e_1_2_3_7_1","unstructured":"For selected reviews see:"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.256"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.03.036"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/b820303b"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300272t"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar500344t"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00137"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1591749"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1719822"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00540"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202300017"},{"key":"e_1_2_3_18_2","volume":"18","author":"Kumar R.","year":"2023","journal-title":"Chem. Asian J."},{"key":"e_1_2_3_19_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja301120z"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja407277a"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b09329"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511235"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702295"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04750"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat4210"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11688-7"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c04558"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18235-9"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02971"},{"key":"e_1_2_3_31_2","volume":"17","author":"Zhou M.","year":"2023","journal-title":"Angew. 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Ed."},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c01396"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00051"},{"key":"e_1_2_3_34_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja208867g"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902642"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01592"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09811"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02892"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01835"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01911"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202303078"},{"key":"e_1_2_3_43_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-31965"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610693"},{"key":"e_1_2_3_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04823"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c01252"},{"key":"e_1_2_3_48_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja803344v"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05850"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0343-5"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.05.017"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf2798"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202309263"},{"key":"e_1_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101517"},{"key":"e_1_2_3_56_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol500513b"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07607"},{"key":"e_1_2_3_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11025"},{"key":"e_1_2_3_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202017175"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01642"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c03545"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c03642"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06246A"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c03947"},{"key":"e_1_2_3_66_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502980"},{"key":"e_1_2_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507550"},{"key":"e_1_2_3_69_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6206"},{"key":"e_1_2_3_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02982"},{"key":"e_1_2_3_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00821"},{"key":"e_1_2_3_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13192"},{"key":"e_1_2_3_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05126"},{"key":"e_1_2_3_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35560-3"},{"key":"e_1_2_3_75_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC05231A"},{"key":"e_1_2_3_76_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_77_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja051181d"},{"key":"e_1_2_3_78_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0680562"},{"key":"e_1_2_3_79_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja074698t"},{"key":"e_1_2_3_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol702061s"},{"key":"e_1_2_3_81_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja506532h"},{"key":"e_1_2_3_82_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11261"},{"key":"e_1_2_3_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13024-5"},{"key":"e_1_2_3_84_1","unstructured":"For selected examples of formation of symmetrical 1 2-diamines see:"},{"key":"e_1_2_3_85_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201103077"},{"key":"e_1_2_3_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01177"},{"key":"e_1_2_3_87_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01443"},{"key":"e_1_2_3_88_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC05335B"},{"key":"e_1_2_3_89_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01308"},{"key":"e_1_2_3_90_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c00228"},{"key":"e_1_2_3_91_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02604"},{"key":"e_1_2_3_92_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03908"},{"key":"e_1_2_3_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202300364"},{"key":"e_1_2_3_94_1","unstructured":"For selected examples see:"},{"key":"e_1_2_3_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201719"},{"key":"e_1_2_3_96_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201209142"},{"key":"e_1_2_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201600393"},{"key":"e_1_2_3_98_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01145"},{"key":"e_1_2_3_99_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1707600"},{"key":"e_1_2_3_100_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c00898"},{"key":"e_1_2_3_101_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00883-3"},{"key":"e_1_2_3_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212292"},{"key":"e_1_2_3_103_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01137"},{"key":"e_1_2_3_104_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c04148"},{"key":"e_1_2_3_105_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c00155"},{"key":"e_1_2_3_106_2","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC00330F"},{"key":"e_1_2_3_107_1","unstructured":"\u00a0"},{"key":"e_1_2_3_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005652"},{"key":"e_1_2_3_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19748-z"},{"key":"e_1_2_3_110_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01313"},{"key":"e_1_2_3_111_1","unstructured":"\u00a0"},{"key":"e_1_2_3_112_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507630"},{"key":"e_1_2_3_113_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat3863"},{"key":"e_1_2_3_114_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008247"},{"key":"e_1_2_3_115_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11083"},{"key":"e_1_2_3_116_1","unstructured":"For reviews see:"},{"key":"e_1_2_3_117_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB00146D"},{"key":"e_1_2_3_118_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC02431D"},{"key":"e_1_2_3_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215257"},{"key":"e_1_2_3_120_1","unstructured":"For selected reviews on HFIP see:"},{"key":"e_1_2_3_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0088"},{"key":"e_1_2_3_122_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05194B"},{"key":"e_1_2_3_123_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC06937J"},{"key":"e_1_2_3_124_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00749"},{"key":"e_1_2_3_125_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsorginorgau.3c00067"},{"key":"e_1_2_3_126_1","unstructured":"In the transformation water coming from the catalyst does not have any influence since it is as efficient with Fe(OTf)2and Fe(OAc)2. Fe(SO4)2.7H2O presents the advantage of being cheap and easy to handle."},{"key":"e_1_2_3_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c01021"},{"key":"e_1_2_3_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202309289"},{"key":"e_1_2_3_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00166"},{"key":"e_1_2_3_130_1","unstructured":"\u00a0"},{"key":"e_1_2_3_131_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700044"},{"key":"e_1_2_3_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.09.091"},{"key":"e_1_2_3_133_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00960"},{"key":"e_1_2_3_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112885"},{"key":"e_1_2_3_135_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201993"},{"key":"e_1_2_3_136_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c04095"},{"key":"e_1_2_3_137_1","unstructured":"For rare examples of aminothiolation of styrenes with alkylthiols see:"},{"key":"e_1_2_3_138_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b02392"},{"key":"e_1_2_3_139_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c02329"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202411992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202411992","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202411992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:26:23Z","timestamp":1790180783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202411992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":139,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2024,11,4]]}},"alternative-id":["10.1002\/anie.202411992"],"URL":"https:\/\/doi.org\/10.1002\/anie.202411992","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"2024-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202411992"}}