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The methodology, which is run employing only 2.5\u2005equivalents of CO and simple Ni(II) salts as the metal source, exhibits a broad substrate scope under mild conditions. Furthermore, this carbonylation chemistry provides an easy switch between isotopologues for stable (\n                    <jats:sup>13<\/jats:sup>\n                    CO) and radioactive (\n                    <jats:sup>14<\/jats:sup>\n                    CO) isotope labeling, allowing its adaptation to the late\u2010stage isotope labeling of pharmaceutically relevant compounds. Based on DFT calculations as well as experimental evidence, a catalytic cycle is proposed involving a carbon\u2010centered radical formed via nickel(I)\u2010induced outer\u2010sphere decarboxylative fragmentation of the redox\u2010active ester.\n                  <\/jats:p>","DOI":"10.1002\/anie.202412247","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T06:44:42Z","timestamp":1723704282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nickel Catalyzed Carbonylative Cross Coupling for Direct Access to Isotopically Labeled Alkyl Aryl Ketones"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-0891","authenticated-orcid":false,"given":"Kim S.","family":"M\u00fchlfenzl","sequence":"first","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"},{"name":"Early Chemical Development Pharmaceutical Sciences, R&amp;D AstraZeneca, Gothenburg  Pepparedsleden 1 43183 M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-2544","authenticated-orcid":false,"given":"Vitus J.","family":"Enem\u00e6rke","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0126-8987","authenticated-orcid":false,"given":"Sahil","family":"Gahlawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry UiT The Arctic University of Norway  Hansine Hansens veg 56 9019 Troms\u00f8"},{"name":"Department of Chemistry Hylleraas Center for Quantum Molecular Sciences UiT The Arctic University of Norway  Hansine Hansens veg 56 9019 Troms\u00f8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter I.","family":"Golb\u00e6kdal","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoline","family":"Munksgaard\u2010Ottosen","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline T.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-716X","authenticated-orcid":false,"given":"Kathrin H.","family":"Hopmann","sequence":"additional","affiliation":[{"name":"Department of Chemistry UiT The Arctic University of Norway  Hansine Hansens veg 56 9019 Troms\u00f8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-0705","authenticated-orcid":false,"given":"Per\u2010Ola","family":"Norrby","sequence":"additional","affiliation":[{"name":"Data Science &amp; Modelling, Pharmaceutical Sciences, R&amp;D AstraZeneca, Gothenburg  Pepparedsleden 1 43183 M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Elmore","sequence":"additional","affiliation":[{"name":"Early Chemical Development Pharmaceutical Sciences, R&amp;D AstraZeneca, Gothenburg  Pepparedsleden 1 43183 M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8090-5050","authenticated-orcid":false,"given":"Troels","family":"Skrydstrup","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) Department of Chemistry Aarhus University  Gustav Wieds Vej 14 8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.11.051"},{"key":"e_1_2_7_3_2","first-page":"515","volume-title":"Annu. 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