{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:52:31Z","timestamp":1790815951434,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Advances in adaptive immunity have greatly contributed to the development of cancer immunotherapy. However, its over\u2010low efficacy and insufficient invasion of immune cells in the tumor tissue, and safety problems caused by cytokine storm, have seriously impeded further clinical application for solid tumor immunotherapy. Notably, the immune microenvironment of the lungs is naturally enriched with alveolar macrophages (AMs). Herein, we introduce a novel nebulized magnetothermal immunotherapy strategy to treat orthotopic lung cancer by using magnetothermal nanomaterial (Zn\u2212CoFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Zn\u2212MnFe\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \u2212PEG, named ZCMP), which can release iron ions via an acid\/thermal\u2010catalytic reaction to maximize the use of lung\u2018s immune environment through the cascade activations of AMs and natural killer (NK) cells. Nebulized administration greatly enhance drug bioavailability by localized drug accumulation at the lesion site. Upon mild magnetic hyperthermia, the released iron ions catalyze endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    decomposition to produce reactive oxygen species (ROS), which triggers the M1 polarization of AMs, and the resultant inflammatory cytokine IFN\u2010\u03b2, IL\u20101\u03b2 and IL\u201015 releases to activate c\u2010Jun, STAT5 and GZMB related signaling pathways, promoting NK cells proliferation and activation. This innovative strategy optimally utilizes the lung\u2018s immune environment and shows excellent immunotherapeutic outcomes against orthotopic lung cancer.\n                  <\/jats:p>","DOI":"10.1002\/anie.202413127","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T22:40:32Z","timestamp":1727649632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nebulized Immunotherapy of Orthotopic Lung Cancer by Mild Magnetothermal\u2013Based Innate Immunity Activations"],"prefix":"10.1002","volume":"64","author":[{"given":"Lizhu","family":"Chen","sequence":"first","affiliation":[{"name":"School of Chemical Science and Engineering Institute of Advanced Study Shanghai Key Laboratory of Chemical Assessment and Sustainability Shanghai Tenth People's Hospital School of Medicine Tongji University  200092 Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Institute of Advanced Study Shanghai Key Laboratory of Chemical Assessment and Sustainability Shanghai Tenth People's Hospital School of Medicine Tongji University  200092 Shanghai P.R. China"},{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences  200050 Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences  200050 Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Institute of Advanced Study Shanghai Key Laboratory of Chemical Assessment and Sustainability Shanghai Tenth People's Hospital School of Medicine Tongji University  200092 Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-195X","authenticated-orcid":false,"given":"Jianlin","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Institute of Advanced Study Shanghai Key Laboratory of Chemical Assessment and Sustainability Shanghai Tenth People's Hospital School of Medicine Tongji University  200092 Shanghai P.R. China"},{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences  200050 Shanghai P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00235-0"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102284"},{"key":"e_1_2_8_3_1","unstructured":"\u00a0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01740-y"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14375"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08550"},{"key":"e_1_2_8_8_2","first-page":"53","volume":"3","author":"Massarelli E.","year":"2014","journal-title":"Transl. 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