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The reaction is catalyzed by copper with a triazolium\u2010ion\u2010derived N\u2010heterocyclic carbene as the chiral ligand and makes use of an Si\u2013B reagent as the silicon pronucleophile. The practical methodology furnishes axially chiral aromatic carbaldehydes decorated with a centrally chiral \u03b1\u2010hydroxysilane moiety in moderate to good yields and with high enantio\u2010 as well as excellent diastereoselectivities. The silicon nucleophile always attacks at the diastereotopic face of either carbonyl group away from the <jats:italic>ortho<\/jats:italic> substituent on the phenyl ring at C1 of the 2,6\u2010dicarbaldehyde\u20101\u2010yl fragment. The resulting axially and centrally chiral products can be further converted into valuable biaryl compounds with hardly any erosion of the enantiomeric excess.<\/jats:p>","DOI":"10.1002\/anie.202414005","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T02:50:19Z","timestamp":1726627819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Enantio\u2010 and Diastereoselective Desymmetrization of 1,1\u2019\u2010Biaryl\u20102,6\u2010Dicarbaldehydes by Copper\u2010Catalyzed 1,2\u2010Addition of Silicon Nucleophiles"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-1108","authenticated-orcid":false,"given":"Yao","family":"Xiao","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Chemie Technische Universit\u00e4t Berlin  Strasse des 17.\u2005Juni 115 10623 Berlin 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